Department of Chemistry, University of Kansas, Lawrence, 66045-7582, United States.
ACS Comb Sci. 2012 Apr 9;14(4):268-72. doi: 10.1021/co2001839. Epub 2012 Mar 5.
A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the utilization of a suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS.
已经成功地将 MACOS 扩展组合和 ROMP 衍生的寡聚三唑磷酸盐(OTP(n))用于制备含有苯并噻嗪-1,1-二氧化物的 106 成员三唑文库。本报告展示了一套可溶性 OTP(n)试剂在无需纯化的过程中用于 10 个 MACOS 衍生的内酰胺支架的简便(三唑基)甲基化,用于高通量筛选小分子集合的平行合成。