Division of General Surgery, Department of Surgery, University of Western Ontario, London, Ontario, Canada.
Injury. 2012 May;43(5):542-7. doi: 10.1016/j.injury.2012.01.020. Epub 2012 Mar 3.
Pulmonary embolisms (PE) are an often preventable cause of late morbidity and mortality after trauma. Although there is evidence for the use of therapeutic inferior vena cava (IVC) filters (defined as IVC filters implanted in those with proven deep venous thrombosis [DVT] in order to prevent PE), there is not as much evidence to support the use of prophylactic IVC filters. Thus, we undertook a systematic review of the literature to assess the following in prophylactic IVC filters: efficacy in PE reduction, prevalence of filter-related complications and the indications for use.
After screening 249 studies, 24 studies met inclusion criteria for qualitative synthesis.
Overall, the literature is supportive of the use of prophylactic IVC filters in high-risk poly-trauma patients who may have contraindications to DVT prophylaxis. Filter-associated complications are uncommon and, when they do occur, tend to be of limited clinical significance. Limited data, mostly in the form of case series, supports a reduction in PE and PE-related mortality. There has been increasing use of retrievable filters as well as the ability to safely retrieve them at longer intervals.
Despite the addition of a few matched-control studies, the literature is still plagued by a lack of high quality data, and therefore the true efficacy of prophylactic IVC filters for prevention of PE in trauma patients remains unclear. Further studies are required to determine the true role of prophylactic IVC filters in trauma patient.
肺栓塞(PE)是创伤后迟发性发病率和死亡率的常见可预防原因。尽管有证据表明可使用治疗性下腔静脉(IVC)滤器(定义为植入那些已证实存在深静脉血栓形成[DVT]以预防 PE 的 IVC 滤器),但支持使用预防性 IVC 滤器的证据并不多。因此,我们对文献进行了系统评价,以评估预防性 IVC 滤器的以下方面:在降低 PE 方面的疗效、滤器相关并发症的发生率以及使用的指征。
在筛选了 249 项研究后,有 24 项研究符合定性综合的纳入标准。
总体而言,文献支持在可能存在 DVT 预防禁忌证的高危多发伤患者中使用预防性 IVC 滤器。滤器相关并发症并不常见,而且即使发生,通常也具有有限的临床意义。有限的数据,主要是病例系列,支持减少 PE 和与 PE 相关的死亡率。可回收滤器的使用越来越多,并且能够在更长的间隔时间内安全地回收它们。
尽管增加了一些匹配对照研究,但文献仍然缺乏高质量的数据,因此预防性 IVC 滤器在创伤患者中预防 PE 的真正疗效仍不清楚。需要进一步的研究来确定预防性 IVC 滤器在创伤患者中的真正作用。