MicroRNA-409-3p 通过靶向 PHF10 调控胃癌细胞增殖和凋亡。
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.
机构信息
Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Cancer Lett. 2012 Jul 28;320(2):189-97. doi: 10.1016/j.canlet.2012.02.030. Epub 2012 Mar 1.
Emerging evidence has indicated microRNAs are involved in tumor development and progression, acting as tumor suppressors or oncogenes. Here we report that miR-409-3p was significantly downregulated in gastric cancer (GC) cell lines and tissues. Overexpression of miR-409-3p in SGC-7901 gastric cancer cells dramatically suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, we demonstrate that the transcriptional regulator PHF10 was a target of miR-409-3p. Taken together, these findings suggest that miR-409-3p may function as a novel tumor suppressor in GC and its anti-oncogenic activity may involve the direct targeting and inhibition of PHF10.
新出现的证据表明，microRNAs 参与肿瘤的发生和发展，作为肿瘤抑制因子或癌基因发挥作用。在这里，我们报告 miR-409-3p 在胃癌（GC）细胞系和组织中显著下调。miR-409-3p 在胃癌 SGC-7901 细胞中的过表达，显著抑制了体外和体内的细胞增殖，并诱导了细胞凋亡。此外，我们证明转录调节因子 PHF10 是 miR-409-3p 的靶标。总之，这些发现表明 miR-409-3p 可能在 GC 中作为一种新型肿瘤抑制因子发挥作用，其抗癌活性可能涉及对 PHF10 的直接靶向和抑制。
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