Demirel Fatma, Aksu Tekin, Esen Ihsan, Yarali Neşe, Karakaya Gülhan, Tunç Bahattin
Department of Pediatric Endocrinology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
Turk J Pediatr. 2011 Nov-Dec;53(6):702-4.
Prasad's syndrome is characterized by geophagia, growth retardation, hypogonadism, and zinc deficiency. We report a 15-year-old boy whose medical history and clinical and laboratory findings were fully compatible with Prasad's syndrome. In addition to severe growth retardation and pubertal delay, iron deficiency anemia and zinc deficiency were determined. His gliadin and endomysium antibodies were negative. The thyroid hormone levels were in normal range but basal gonadotropins and testosterone levels were low for his age. Detailed endocrinological evaluation revealed growth hormone deficiency and hypogonadotropic hypogonadism. Pituitary gland magnetic resonance imaging revealed pituitary hypoplasia. In our opinion, before the diagnosis of Prasad's syndrome, endocrine evaluation should be done in these patients and hypopituitarism should be ruled out. Hypogonadotropic hypogonadism and growth hormone deficiency may be masked by Prasad's syndrome.
普拉萨德综合征的特征为食土癖、生长发育迟缓、性腺功能减退和锌缺乏。我们报告一名15岁男孩，其病史、临床及实验室检查结果与普拉萨德综合征完全相符。除严重生长发育迟缓及青春期延迟外，还发现有缺铁性贫血和锌缺乏。其麦醇溶蛋白和肌内膜抗体均为阴性。甲状腺激素水平在正常范围内，但基础促性腺激素和睾酮水平低于其年龄应有值。详细的内分泌评估显示生长激素缺乏和低促性腺激素性性腺功能减退。垂体磁共振成像显示垂体发育不全。我们认为，在诊断普拉萨德综合征之前，应对这些患者进行内分泌评估并排除垂体功能减退。低促性腺激素性性腺功能减退和生长激素缺乏可能被普拉萨德综合征所掩盖。
