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低流量气管内输氧:能力与局限

Tracheal insufflation of oxygen at low flow: capabilities and limitations.

作者信息

Mackenzie C F, Barnas G, Nesbitt S

机构信息

Department of Anesthesiology, University of Maryland Medical System, Baltimore 21201.

出版信息

Anesth Analg. 1990 Dec;71(6):684-90. doi: 10.1213/00000539-199012000-00019.

DOI:10.1213/00000539-199012000-00019
PMID:2240643
Abstract

Tracheal insufflation of oxygen (TRIO) may provide temporary oxygenation for patients or sustain life in apneic mass casualties when conventional ventilatory techniques are not available or feasible. Logistically, minimum flows of TRIO (Vmin) are desirable for field use and to reduce barotrauma should airway obstruction occur. We carried out a feasibility study to determine the efficacy of Vmin of TRIO delivered within 1 cm of the carina, in nine anesthetized and paralyzed dogs. Minimum flows of TRIO for these dogs of average weight (12 kg) was 91 mL/min. In six of the dogs Vmin TRIO was continued and provided oxygenation for an average of 1.5 h compatible with subsequent resuscitation with conventional ventilation. However, PaCO2 levels increased to mean values of 256 mm Hg in the 90 min. To determine what the effect of increased gas mixing was on gas exchange, we repeated Vmin TRIO for 10 min in six of the dogs with and without high frequency oscillations superimposed on the TRIO flow. The oscillations (60 mL at 16.3 Hz) increased carbon dioxide excretion but significantly impaired oxygenation. In completely apneic animals, TRIO at low flow delivered by cricothyroidotomy may be useful as an emergency procedure when upper airway obstruction limits the use of other airway management techniques. However, enhancement of gas mixing during low-flow TRIO impairs oxygenation, so that higher flows would be required when respiratory efforts occur.

摘要

当无法获得或无法实施传统通气技术时,经气管吹入氧气(TRIO)可为患者提供临时氧合或维持呼吸暂停的大批伤亡人员的生命。从后勤角度来看,TRIO的最小流量(Vmin)有利于现场使用,并在发生气道阻塞时减少气压伤。我们进行了一项可行性研究,以确定在9只麻醉和麻痹的犬中,在隆突1厘米范围内输送的TRIO的Vmin的效果。这些平均体重为12千克的犬的TRIO最小流量为91毫升/分钟。在6只犬中持续进行Vmin TRIO,并提供了平均1.5小时的氧合,这与随后的传统通气复苏相容。然而,在90分钟内,动脉血二氧化碳分压(PaCO2)水平升至平均256毫米汞柱。为了确定增加气体混合对气体交换的影响,我们在6只犬中重复进行了10分钟的Vmin TRIO,其中3只犬在TRIO气流上叠加了高频振荡,另外3只犬未叠加高频振荡。振荡(频率为16.3赫兹,容积为60毫升)增加了二氧化碳排出,但显著损害了氧合。在完全呼吸暂停的动物中,当其他气道管理技术因上气道阻塞而受到限制时,环甲膜切开术低流量输送TRIO可能作为一种紧急措施有用。然而,低流量TRIO期间增强气体混合会损害氧合,因此当出现呼吸努力时需要更高的流量。

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Tracheal insufflation of oxygen at low flow: capabilities and limitations.低流量气管内输氧:能力与局限
Anesth Analg. 1990 Dec;71(6):684-90. doi: 10.1213/00000539-199012000-00019.
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Laryngoscope Investig Otolaryngol. 2018 Aug 9;3(4):296-303. doi: 10.1002/lio2.173. eCollection 2018 Aug.
2
Influence of apneic oxygenation on cardiorespiratory system homeostasis.窒息性氧合对心肺系统稳态的影响。
J Anesth. 2014 Apr;28(2):172-9. doi: 10.1007/s00540-013-1714-5. Epub 2013 Sep 24.