最近对氨甲酰酯类毒素的致死效力进行了评估。
A recent evaluation of the lethal potencies of ammodytoxins.
机构信息
Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva cesta 5, SI-1000 Ljubljana, Slovenia.
出版信息
Toxicon. 2012 May;59(6):642-3. doi: 10.1016/j.toxicon.2012.02.009. Epub 2012 Mar 3.
Ammodytoxin A (AtxA) is the most toxic secreted phospholipase A(2) of the three isotoxins with presynaptic neurotoxicity, isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes), with an LD(50) of 21 μg/kg in mice. The toxic potencies of two other isoforms have been re-evaluated using highly purified recombinant proteins, with their intraperitoneal LD(50)s determined as 960 μg/kg for AtxB and 310 μg/kg for AtxC. AtxB and AtxC differ from AtxA in only three and two amino acid residues, respectively.
氨酷毒素 A (AtxA) 是从鼻角蝰（Vipera ammodytes ammodytes）毒液中分离出的三种同工毒素中最具毒性的分泌型磷脂酶 A₂，具有突触前神经毒性，其在小鼠中的 LD₅₀ 为 21μg/kg。使用高度纯化的重组蛋白重新评估了另外两种同工型的毒力，其腹腔内 LD₅₀ 分别为 960μg/kg 的 AtxB 和 310μg/kg 的 AtxC。AtxB 和 AtxC 与 AtxA 仅分别在三个和两个氨基酸残基上存在差异。
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