（Z）-或（E）-烯炔基乙酸酯合成多取代呋喃：芳环供电子基团加速的串联反应。
Multisubstituted furan formation from (Z)- or (E)-enynyl acetates: tandem reactions accelerated by electron-donating groups on aromatic rings.
机构信息
Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
出版信息
J Org Chem. 2012 Apr 20;77(8):3944-51. doi: 10.1021/jo300251c. Epub 2012 Mar 29.
PMID:22439794
Abstract
Multisubstituted furans were readily prepared from (Z)- or (E)-conjugated enynyl acetates with NXS under metal-free conditions at room temperature via the same haloallenyl ketone intermediates. This tandem haloallenyl ketone formation-furan formation reaction sequence was accelerated by electron-donating groups on the aromatic rings.
摘要
多取代呋喃可通过（Z）-或（E）-共轭烯炔基乙酸酯与 NXS 在室温下无金属条件下简便地制备，通过相同的卤代烯基酮中间体。该串联卤代烯基酮形成-呋喃形成反应序列被芳环上的供电子基团加速。
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