Vannemreddy Prasad S S V, Nourbakhsh Ali, Nanda Anil
Skull Base. 2011 Jan;21(1):37-46. doi: 10.1055/s-0030-1263285.
The indicators of poor outcome in giant intracranial aneurysms have been the subject of several studies in the literature. We conducted a retrospective analysis to evaluate the predictors of poor outcome in giant intracranial aneurysms. We studied consecutive cases with aneurysms admitted over a 9-year period in our institution. All the aneurysms were treated with clipping. Patient demographics, clinical profile, and aneurysm characteristics were evaluated in a multivariate analysis as probable indicators of Glasgow Outcome Scale (GOS) score. The outcome of the aneurysms (GOS score) was compared with the remaining non-giant aneurysms. A total of 41 giant and 348 non-giant aneurysms were identified in our series. In the multivariate analysis, the indicators of poor outcome were identified as poor clinical grade (p < 0.0004), intraoperative rupture (p < 0.007), and posterior circulation of the aneurysms (p < 0.01). Non-giant aneurysms had a better outcome compared with the giant aneurysms (p < 0.01). Giant aneurysms impose a relatively higher risk of morbidity and mortality to the patients. The predictors of the postsurgical outcome of the giant aneurysms include the clinical condition of the patient, location of the aneurysm, and intraoperative rupture.
巨大颅内动脉瘤预后不良的指标一直是文献中多项研究的主题。我们进行了一项回顾性分析，以评估巨大颅内动脉瘤预后不良的预测因素。我们研究了在我们机构9年期间收治的连续动脉瘤病例。所有动脉瘤均采用夹闭术治疗。在多变量分析中评估患者人口统计学、临床特征和动脉瘤特征，将其作为格拉斯哥预后量表（GOS）评分的可能指标。将动脉瘤的预后（GOS评分）与其余非巨大动脉瘤进行比较。在我们的系列研究中，共识别出41例巨大动脉瘤和348例非巨大动脉瘤。在多变量分析中，预后不良的指标被确定为临床分级差（p＜0.0004）、术中破裂（p＜0.007）以及动脉瘤的后循环（p＜0.01）。与巨大动脉瘤相比，非巨大动脉瘤的预后更好（p＜0.01）。巨大动脉瘤给患者带来相对较高的发病和死亡风险。巨大动脉瘤术后预后的预测因素包括患者的临床状况、动脉瘤的位置和术中破裂情况。
