抗神经元α7-乙酰胆碱受体抗体在重症肌无力中的作用。

Role of antibodies to neuronal α7-acetylcholine receptors in myasthenia.

作者信息

Lantzova V B, Sepp E K, Kozlovskii A S

机构信息

Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2011 Jul;151(3):305-7. doi: 10.1007/s10517-011-1315-y.

DOI:10.1007/s10517-011-1315-y

PMID:22451872

Abstract

The role of antibodies to a fragment of neuronal acetylcholine receptor was studied by EIA in patients with myasthenia. Antibody levels were significantly higher in patients with generalized myasthenia. Enzyme immunoassay of antibodies by the reaction with acetylcholine receptor fragment can serve as an additional method for studies of autoimmune myasthenia pathogenesis.

摘要

采用酶免疫测定法（EIA）研究了抗神经元乙酰胆碱受体片段抗体在重症肌无力患者中的作用。全身型重症肌无力患者的抗体水平显著更高。通过与乙酰胆碱受体片段反应进行抗体的酶免疫测定可作为研究自身免疫性重症肌无力发病机制的一种辅助方法。