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凝血标志物在轻度蛇咬伤中的作用。

The role for coagulation markers in mild snakebite envenomations.

机构信息

University of Mississippi Medical Center, Department of Emergency Medicine, Jackson, Mississippi.

出版信息

West J Emerg Med. 2012 Feb;13(1):68-74. doi: 10.5811/westjem.2011.6.6729.

Abstract

INTRODUCTION

The majority of patients seeking medical treatment for snakebites do not suffer from severe envenomation. However, no guidelines exist for ordering coagulation markers in patients with minimal or moderate envenomation, nor in those who do not receive antivenom. In this study, we sought to determine whether it was possible to limit the practice of ordering coagulation studies to those patients suffering severe envenomation, rattlesnake envenomation, or both.

METHODS

A retrospective chart review was performed on all cases of crotalid snakebite presenting to an adult emergency department (ED) from April 1998 to June 2006. Each chart was abstracted for patient's age, gender, type of snake (if known), severity of envenomation at initial presentation, coagulation test results, whether antivenom was administered, and whether the patient was admitted.

RESULTS

Over an approximately 8-year period, 131 snakebite cases presented that met the inclusion criteria, of which 35 (26.7%) had some type of coagulation marker abnormality. Limiting coagulation testing to patients suffering severe envenomation or rattlesnake envenomation would have resulted in failure to identify 89% or 77%, respectively, of the 35 patients who were found to have at least 1 abnormal coagulation marker.

CONCLUSION

Our study failed to identify a subset of patients that could be defined as low risk or for whom coagulation marker testing could be foregone. This study suggests that coagulation tests should be routinely performed on all patients presenting to the ED with complaints of envenomation by copperheads, moccasins, or rattlesnakes. Further clarification of when coagulation markers are indicated may require a prospective study that standardizes snake identification and the timing of coagulation marker testing.

摘要

简介

大多数因蛇伤就诊的患者并未遭受严重的蛇毒中毒。然而,对于轻度或中度中毒且未接受抗蛇毒血清治疗的患者,以及中毒不严重的响尾蛇咬伤患者,目前尚无关于凝血标志物检测的指南。本研究旨在确定是否可以将凝血检测仅限于重度中毒、响尾蛇咬伤或两者兼有的患者。

方法

对 1998 年 4 月至 2006 年 6 月期间在成人急诊科就诊的所有眼镜蛇咬伤患者进行回顾性图表审查。每个图表都记录了患者的年龄、性别、蛇的种类(如果已知)、初次就诊时的中毒严重程度、凝血试验结果、是否给予抗蛇毒血清以及是否住院。

结果

在大约 8 年的时间里,符合纳入标准的蛇咬伤病例有 131 例,其中 35 例(26.7%)存在某种类型的凝血标志物异常。将凝血检测仅限于重度中毒或响尾蛇中毒患者,将分别导致未能识别 89%和 77%的 35 例存在至少 1 项异常凝血标志物的患者。

结论

我们的研究未能确定一组可以定义为低风险或可以避免进行凝血标志物检测的患者。本研究表明,对于因铜斑蛇、莫卡辛或响尾蛇咬伤而就诊的急诊科患者,应常规进行凝血检测。进一步明确何时需要进行凝血标志物检测可能需要进行一项前瞻性研究,以标准化蛇类鉴定和凝血标志物检测的时间。

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