血管紧张素II介导的焦虑和情绪障碍与NADPH氧化酶诱导的氧化应激之间的联系。
The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.
作者信息
Liu Feng, Havens Jennifer, Yu Qi, Wang Gang, Davisson Robin L, Pickel Virginia M, Iadecola Costantino
出版信息
Int J Physiol Pathophysiol Pharmacol. 2012;4(1):28-35. Epub 2012 Feb 15.
Abstract
The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.
摘要
肾素-血管紧张素系统（RAS）及其活性肽血管紧张素II（AngII）不仅在高血压中起主要作用，还与情绪和焦虑障碍有关。大量证据支持AngII在大脑中作为神经调节剂发挥作用的观点。在本综述中，我们概述了RAS与焦虑或情绪障碍之间的联系，并重点关注对中枢神经系统中与AngII相关的、NADPH氧化酶衍生的氧化应激的最新认识进展，这可能是情绪和焦虑障碍发病机制的基础。
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