Eye Pathology Institute, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol. 2013 May;91(3):195-206. doi: 10.1111/j.1755-3768.2012.02402.x. Epub 2012 Apr 4.
Epithelial tumours of the lacrimal gland represent a large spectrum of lesions with similarities in clinical signs and symptoms but with different biological behaviour and prognosis. They are rare, but with aggressive malignant potential. Tumours of the lacrimal gland may present with swelling of the lacrimal gland, displacement of the eyeball, reduced eye motility and diplopia. Pain and symptoms of short duration before the first ophthalmic consultation are characteristic of malignant tumours. The histological diagnosis determines the subsequent treatment regimen and provides important clues regarding the prognosis. The purpose of this paper is to describe the various primary epithelial tumours of the lacrimal gland. In the first part of the review, the frequency, demographics, clinical presentation and diagnostic features are described. In the second part, primarily tumour-specific histological characteristics are given. Finally, treatment modalities including surgical procedures and medical oncology as well as prognosis are discussed.
泪腺上皮性肿瘤是一组具有相似临床特征和症状的病变，但具有不同的生物学行为和预后。它们比较罕见，但具有侵袭性恶性潜能。泪腺肿瘤可表现为泪腺肿胀、眼球移位、眼球运动受限和复视。疼痛和较短的症状持续时间是恶性肿瘤的特征。组织学诊断决定了后续的治疗方案，并为预后提供了重要线索。本文旨在描述各种原发性泪腺上皮性肿瘤。在综述的第一部分，描述了其频率、人口统计学、临床表现和诊断特征。在第二部分，主要给出了肿瘤特异性的组织学特征。最后，讨论了包括手术和肿瘤内科在内的治疗方式以及预后。
