全胃切除的T3期胃癌患者中转移淋巴结比率的预后意义
Prognostic significance of the metastatic lymph node ratio in T3 gastric cancer patients undergoing total gastrectomy.
作者信息
Feng Jun, Wu Yun-Fei, Xu Hui-Mian, Wang Shu-Bao, Chen Jun-Qing
机构信息
Department of Surgical Oncology, Fudan University, Taizhou, Zhejiang Province, China.
出版信息
Asian Pac J Cancer Prev. 2011;12(12):3289-92.
AIMS AND BACKGROUND
The International Union Against Cancer tumor node metastasis classification is routinely applied for evaluating the prognosis of patients with gastric cancer. However, results are still heterogeneous. This study was therefore carried out to evaluate the prognostic significance of the metastatic lymph node (LN) ratio in T3 gastric cancer patients undergoing gastrectomy.
METHODS
Clinical data of 109 LN- positive cases were retrospectively analyzed. Spearman correlation analysis was used to determine the correlation coefficiency. Survival time was determined by Kaplan-Meier and Log-rank test. Multivariate analysis was performed using the Cox model. ROC curves were used to compare the accuracy of the number of metastatic LN and metastatic LN ratio.
RESULTS
The metastatic LN ratio did not correlate with the number of LN when at least 15 nodes were dissected, whereas the number of metastatic LN did. Univariate analysis showed that the metastatic LN ratio influenced significantly the survival time, while multivariate analysis revealed it to be a major independent prognostic factor.
CONCLUSIONS
The metastatic LN ratio can be used as a major independent prognostic factor for the patients with T3 gastric cancer.
目的与背景
国际抗癌联盟的肿瘤淋巴结转移分类法通常用于评估胃癌患者的预后。然而，结果仍存在异质性。因此，本研究旨在评估接受胃切除术的T3期胃癌患者中转移淋巴结（LN）比率的预后意义。
方法
回顾性分析109例LN阳性病例的临床资料。采用Spearman相关分析确定相关系数。生存时间通过Kaplan-Meier法和对数秩检验确定。使用Cox模型进行多变量分析。采用ROC曲线比较转移LN数量和转移LN比率的准确性。
结果
当至少切除15个淋巴结时，转移LN比率与LN数量不相关，而转移LN数量相关。单变量分析显示转移LN比率显著影响生存时间，而多变量分析表明它是一个主要的独立预后因素。
结论
转移LN比率可作为T3期胃癌患者的主要独立预后因素。
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