Department of Otolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Sendai, 980-8574 Japan.
Head Neck. 2012 Nov;34(11):1537-41. doi: 10.1002/hed.21984. Epub 2012 Mar 31.
Mucosal melanoma of the head and neck is rare and is associated with a poor prognoses because of locoregional failure and distant metastasis. The aim of our study was to review the characteristics of these patients in northern Japan and to analyze their outcomes.
The medical records of 94 patients who had been provided initial treatment in 12 institutes from 1998 to 2007 were reviewed.
When the 5-year overall survival rates of patients were evaluated, we found that the survival rates of patients treated by chemotherapy were significantly lower than those of patients treated by surgery or radiation. The survival rates of the single-treatment modality, 2-modality, and ≥3-modality groups were 23.4%, 38.0%, and 33.6%, respectively.
Our results suggest that patients who underwent combined treatment had better prognoses. However, we found that chemotherapy had no additional survival benefits.
头颈部黏膜黑色素瘤较为罕见，由于局部区域复发和远处转移，预后较差。本研究的目的是回顾日本北部此类患者的特征，并分析其结局。
对 1998 年至 2007 年间 12 家机构提供初始治疗的 94 例患者的病历进行了回顾。
评估患者 5 年总生存率时，我们发现化疗组患者的生存率明显低于手术或放疗组。单一治疗方式、两种治疗方式和≥3 种治疗方式组的生存率分别为 23.4%、38.0%和 33.6%。
我们的结果表明，接受联合治疗的患者具有更好的预后。然而，我们发现化疗并没有带来额外的生存获益。
