Department of Pathology, Research Institute for Clinical Medicine, Research Institute for Endocrine Sciences, Chonbuk National University Medical School, Jeonju-city, Jeonbuk, South Korea.
Ann Diagn Pathol. 2013 Feb;17(1):108-12. doi: 10.1016/j.anndiagpath.2012.03.001. Epub 2012 Apr 2.
Myoid angioendothelioma of the spleen is an uncommon, benign vascular tumor that is morphologically characterized by a composite of vascular spaces and stromal cells with myoid feature. Herein, we report a case of the myoid angioendothelioma of the spleen, concurrent with rectal adenocarcinoma. A 41-year-old woman presented with hematochezia for several weeks. Grossly, the rectal mass was a 2.5 × 2-cm ulcerative fungating lesion. The splenic mass was a 2.2 × 2-cm well-circumscribed lesion. Microscopically, the rectal mass was a well-differentiated adenocarcinoma that invaded into the pericolic adipose tissue. The splenic mass was composed of slit-like vascular spaces and fascicles of elongated stromal cells. Vascular endothelial cells were immunopositive for CD31, factor VIII-related antigen, and CD34 but negative for CD8. Stromal cells were immunopositive for smooth muscle actin but negative for desmin.
脾脏的肌样血管内皮细胞瘤是一种罕见的良性血管肿瘤，其形态学特征为血管腔和具有平滑肌样特征的基质细胞的复合。本文报道了一例脾脏肌样血管内皮细胞瘤合并直肠腺癌。一名 41 岁女性因便血数周就诊。直肠肿块大体上为 2.5×2cm 的溃疡性外生性病变。脾脏肿块为 2.2×2cm 的边界清楚的病变。镜下，直肠肿块为分化良好的腺癌，侵犯结肠旁脂肪组织。脾脏肿块由缝隙样血管腔和束状拉长的基质细胞组成。血管内皮细胞免疫组化 CD31、VIII 因子相关抗原和 CD34 阳性，而 CD8 阴性。基质细胞平滑肌肌动蛋白阳性，结蛋白阴性。
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