Respiratory Department, Peking University Third Hospital, Beijing, China.
Respir Physiol Neurobiol. 2012 Nov 15;184(2):130-8. doi: 10.1016/j.resp.2012.03.009. Epub 2012 Mar 20.
Hydrogen sulfide (H(2)S) is an important gasotransmitter in the mammalian respiratory system. The enzymes that produce H(2)S - mainly cystathionine-β-synthase and cystathionine-γ-lyase - are expressed in pulmonary and airway tissues. Endogenous H(2)S participates in the regulation of the respiratory system's physiological functions and pathophysiological alterations, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis and hypoxia-induced pulmonary hypertension, to name a few. The cellular targets of H(2)S in the respiratory system are diverse, including airway smooth muscle cells, epithelial cells, fibroblasts, and pulmonary artery smooth muscle cells. H(2)S also regulates respiratory functions such as airway constriction, pulmonary circulation, cell proliferation or apoptosis, fibrosis, oxidative stress, and neurogenic inflammation. Cross-talk between H(2)S and other gasotransmitters also affects the net outcome of lung function. The metabolism of H(2)S in the lungs and airway may serve as a biomarker for specific respiratory diseases. It is expected that strategies targeted at the metabolism and function of H(2)S will prove useful for the prevention and treatment of selective chronic respiratory diseases.
硫化氢 (H(2)S) 是哺乳动物呼吸系统中的一种重要气体递质。产生 H(2)S 的酶——主要是胱硫醚-β-合酶和胱硫醚-γ-裂合酶——在肺部和气道组织中表达。内源性 H(2)S 参与调节呼吸系统的生理功能和病理生理改变，如慢性阻塞性肺疾病、哮喘、肺纤维化和缺氧性肺动脉高压等。H(2)S 在呼吸系统中的细胞靶标多种多样，包括气道平滑肌细胞、上皮细胞、成纤维细胞和肺动脉平滑肌细胞。H(2)S 还调节气道收缩、肺循环、细胞增殖或凋亡、纤维化、氧化应激和神经源性炎症等呼吸功能。H(2)S 与其他气体递质之间的相互作用也会影响肺功能的净结果。肺部和气道中 H(2)S 的代谢可能可作为特定呼吸系统疾病的生物标志物。预计针对 H(2)S 代谢和功能的策略将有助于预防和治疗选择性慢性呼吸系统疾病。
