J Biol Rhythms. 2012 Apr;27(2):172-5. doi: 10.1177/0748730411435209.
Spina bifida meningomyelocele (SBM) is a neural tube defect that involves dysraphism of the spinal cord and extensive reorganization of the brain. The authors assessed the relationship between chronotype, diurnal preferences, and sleep problems in individuals with SBM and healthy controls. Although individuals with SBM showed the characteristic decelerating quadratic relationship between age and chronotype, the curve was displaced, peaking at a younger age in controls compared with SBM (23.4 vs. 29.2 years). Groups did not differ in morningness-eveningness preferences. Individuals with SBM endorsed more sleep problems than controls. Further examination of the relationship between entrainment and sleep in SBM is warranted.
脊髓脊膜膨出(SBM)是一种神经管缺陷,涉及脊髓的发育异常和大脑的广泛重组。作者评估了 SBM 患者和健康对照组中昼夜类型、昼夜节律偏好和睡眠问题之间的关系。尽管 SBM 患者表现出年龄与昼夜类型之间的特征性减速二次关系,但曲线发生了偏移,与 SBM 相比,对照组的峰值出现在更年轻的年龄(23.4 岁对 29.2 岁)。两组在早晚偏好上没有差异。SBM 患者的睡眠问题比对照组更严重。进一步研究 SBM 中的同步与睡眠之间的关系是必要的。