McNair Erick D, Wells Calvin R, Qureshi A Mabood, Basran Rashpal S, Pearce Colin, Orvold Jason, Devilliers Jacobus, Prasad Kailash
Department of Pathology;
Int J Angiol. 2009 Winter;18(4):187-92. doi: 10.1055/s-0031-1278352.
Interaction of the receptors for advanced glycation end products (RAGEs) with advanced glycation end products (AGEs) results in expression of inflammatory mediators (tumor necrosis factor-alpha [TNF-α] and soluble vascular cell adhesion molecule-1 [sVCAM-1]), activation of nuclear factor-kappa B and induction of oxidative stress - all of which have been implicated in atherosclerosis. Soluble RAGE (sRAGE) acts as a decoy for the RAGE ligand and is protective against atherosclerosis.
To determine whether levels of serum sRAGE are lower, and whether levels of serum AGEs, TNF-α and sVCAM-1 are higher in non-ST elevation myocardial infarction (NSTEMI) patients than in healthy control subjects; and whether sRAGE or the ratio of AGEs to sRAGE (AGEs/sRAGE) is a predictor/biomarker of NSTEMI.
Serum levels of sRAGE, AGEs, TNF-α and sVCAM-1 were measured in 46 men with NSTEMI and 28 age- and sex-matched control subjects. Angiography was performed in the NSTEMI patients.
sRAGE levels were lower, and levels of AGEs, TNF-α, sVCAM-1 and AGEs/sRAGE were higher in NSTEMI patients than in control subjects. sRAGE levels were negatively correlated with the number of diseased coronary vessels, serum AGEs, AGEs/sRAGE, TNF-α and sVCAM-1. The sensitivity of the AGEs/sRAGE test is greater than that of the sRAGE test, while the specificity and predictive values of the sRAGE test are greater than those of the AGEs/sRAGE test for identifying NSTEMI patients.
Serum levels of sRAGE were low in NSTEMI patients, and were negatively correlated with extent of lesion, inflammatory mediators, AGEs and AGEs/sRAGE. Both sRAGE and AGEs/sRAGE may serve as biomarkers/predictors for identifying NSTEMI patients.
晚期糖基化终末产物受体（RAGEs）与晚期糖基化终末产物（AGEs）相互作用会导致炎症介质（肿瘤坏死因子-α [TNF-α] 和可溶性血管细胞黏附分子-1 [sVCAM-1]）的表达、核因子-κB的激活以及氧化应激的诱导，所有这些都与动脉粥样硬化有关。可溶性RAGE（sRAGE）作为RAGE配体的诱饵，对动脉粥样硬化具有保护作用。
确定非ST段抬高型心肌梗死（NSTEMI）患者血清sRAGE水平是否低于健康对照者，血清AGEs、TNF-α和sVCAM-1水平是否高于健康对照者；以及sRAGE或AGEs与sRAGE的比值（AGEs/sRAGE）是否为NSTEMI的预测指标/生物标志物。
测定46例男性NSTEMI患者和28例年龄及性别匹配的对照者血清中sRAGE、AGEs、TNF-α和sVCAM-1的水平。对NSTEMI患者进行血管造影检查。
NSTEMI患者的sRAGE水平较低，而AGEs、TNF-α、sVCAM-1水平及AGEs/sRAGE高于对照者。sRAGE水平与病变冠状动脉血管数量、血清AGEs、AGEs/sRAGE、TNF-α和sVCAM-1呈负相关。在识别NSTEMI患者方面，AGEs/sRAGE检测的敏感性高于sRAGE检测，而sRAGE检测的特异性和预测价值高于AGEs/sRAGE检测。
NSTEMI患者血清sRAGE水平较低，且与病变程度、炎症介质、AGEs及AGEs/sRAGE呈负相关。sRAGE和AGEs/sRAGE均可作为识别NSTEMI患者的生物标志物/预测指标。
