Karolinska Institutet, Cardiology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Life Sci. 2012 Oct 15;91(13-14):507-16. doi: 10.1016/j.lfs.2012.03.029. Epub 2012 Mar 28.
Endothelin-1 (ET-1) is a vasoconstrictor, proinflammatory and proliferative endothelial cell-derived peptide that is of significant importance in the regulation of vascular function. It is involved in the development of endothelial dysfunction including important interactions with nitric oxide. The expression and functional effects of ET-1 and its receptors are markedly altered during development of cardiovascular disease. Increased production of ET-1 and its receptors mediate many pathophysiological events contributing to the development of atherosclerosis and vascular complications in diabetes mellitus. The present review focuses on the pathophysiological role of ET-1 and the potential importance of ET receptors as a therapeutic target for treatment of these conditions.
内皮素-1（ET-1）是一种血管收缩、促炎和增殖的内皮细胞衍生肽，在调节血管功能方面具有重要意义。它参与内皮功能障碍的发展，包括与一氧化氮的重要相互作用。ET-1 及其受体的表达和功能效应在心血管疾病的发展过程中发生明显改变。ET-1 和其受体的产生增加介导许多病理生理事件，导致动脉粥样硬化和糖尿病血管并发症的发展。本综述重点介绍了 ET-1 的病理生理作用以及 ET 受体作为这些疾病治疗靶点的潜在重要性。
