Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil.
Life Sci. 2012 May 15;90(17-18):666-72. doi: 10.1016/j.lfs.2012.03.005. Epub 2012 Mar 28.
In this study we investigated the effect of pre-treatment with 3-alkynyl selenophene (3-ASP) against the increase in responsiveness to pentylenetetrazole [PTZ seizure threshold] and cognitive dysfunction induced by experimental febrile seizures (FS). The effects of 3-ASP were compared to those of diazepam (DZP).
Young rats, at postnatal day 21, developed seizures after exposure to a stream of heated air to approximately 41°C. A non-spatial long-term memory and PTZ seizure threshold were determined 30 days after FS. The behavioural seizures were stereotyped followed by facial automatisms, often followed by body flexion. Young rats were pre-treated with 3-ASP (50 and 100mg/kg; per oral route), DZP (1 and 5mg/kg; intraperitoneally) or vehicle.
3-ASP and DZP pre-treatments were not effective in protecting against seizures induced by FS. 3-ASP pre-treatment protected against the increase in responsiveness to PTZ and cognitive dysfunction induced by FS. DZP pre-treatment was effective in protecting against the increase in responsiveness to PTZ, but not, against the impaired memory induced by FS.
3-ASP pre-treatment protected against impairment of memory performance in the step-down passive avoidance task and the increase in the susceptibility to seizures caused by FS early in life of rats.
本研究旨在探讨 3-炔基硒吩（3-ASP）预处理对戊四氮（PTZ）发作阈值升高和实验性热性惊厥（FS）引起的认知功能障碍的影响。将 3-ASP 的作用与地西泮（DZP）进行了比较。
出生后第 21 天的幼鼠在暴露于约 41°C 的热空气中后会发生惊厥。FS 后 30 天测定非空间长期记忆和 PTZ 发作阈值。行为性惊厥表现为刻板性，随后出现面部自动症，常伴有身体弯曲。幼鼠用 3-ASP（50 和 100mg/kg；口服）、DZP（1 和 5mg/kg；腹腔内）或载体进行预处理。
3-ASP 和 DZP 预处理不能有效预防 FS 引起的惊厥。3-ASP 预处理可防止 FS 引起的 PTZ 反应性增加和认知功能障碍。DZP 预处理可有效预防 PTZ 反应性增加，但不能预防 FS 引起的记忆损伤。
3-ASP 预处理可防止大鼠生命早期 FS 引起的记忆表现下降和对惊厥易感性增加。
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