[Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia].

作者信息

Sun Meng-meng, Liu Lan-fen, Yang Li-min, Wang Yan, Cui Kai-yan, Wang Li-na, Li Cui-luan, Qiao Dong-dong, Wang Ru-zhan

机构信息

School of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Apr;29(2):155-8. doi: 10.3760/cma.j.issn.1003-9406.2012.02.008.

DOI:10.3760/cma.j.issn.1003-9406.2012.02.008

PMID:22487823

Abstract

OBJECTIVE

To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.

METHODS

Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).

RESULTS

A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.

CONCLUSION

BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.

摘要