棱柱体相关的富含天冬氨酸序列与镁离子（Mg(II)）对矿物质生长的协同调节作用

Cooperative modulation of mineral growth by prismatic-associated Asprich Sequences and Mg(II).

作者信息

Kim Il Won, Collino Sebastiano, Evans John Spencer

机构信息

Department of Chemical Engineering, Soongsil University, Seoul 156-743, South Korea.

Laboratory for Chemical Physics, New York University, New York, NY 10010, USA.

出版信息

Int J Mol Sci. 2012;13(3):3949-3958. doi: 10.3390/ijms13033949. Epub 2012 Mar 22.

DOI:10.3390/ijms13033949

PMID:22489191

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3317751/

Abstract

Cooperative effects of magnesium ions and acidic polypeptides originating from a family of proteins known as Asprich (mollusk Atrina rigida) were studied. In our previous studies, these two acidic polypeptides were found to be effective in controlling the morphology of the calcium carbonate mineral, the main inorganic constituent of prismatic layer of the mollusk shell. Since these Asprich sequences are believed to contain a putative magnesium binding domain, the morphology-controlling effects were further investigated with the addition of magnesium ions. The mineral morphology was dramatically changed by the combined influence of each polypeptides and the magnesium ions, substantiating the recognized importance of magnesium in the formation of calcium carbonate-based biominerals.

摘要

研究了镁离子与源自一种名为Asprich（软体动物坚海笋）的蛋白质家族的酸性多肽的协同作用。在我们之前的研究中，发现这两种酸性多肽对控制碳酸钙矿物的形态有效，碳酸钙矿物是软体动物贝壳棱柱层的主要无机成分。由于这些Asprich序列被认为含有一个假定的镁结合结构域，因此通过添加镁离子进一步研究了其形态控制作用。每种多肽和镁离子的联合作用显著改变了矿物形态，证实了镁在碳酸钙基生物矿物形成中的重要性。