Horsmans Y, Desager J P, Harvengt C
Laboratoire de pharmacothérapie, université catholique de Louvain, Bruxelles, Belgique.
Bull Cancer. 1990;77(10):985-9.
A retrospective comparison of urinary excretion of norepinephrine, epinephrine, dopamine and/or their acidic metabolites, HVA and VMA, in 36 children with neuroblastoma versus 360 hospitalized children without neuroblastoma showed a sensibility of 72% and a specificity of 98% for HVA and 80% and 97% for VMA respectively. Consequently, the sensibilities and specificities of these 2 determinations confirm their useful purpose for the biochemical diagnosis of neuroblastoma in preference to the determinations of norepinephrine, epinephrine and dopamine.
对36例神经母细胞瘤患儿与360例非神经母细胞瘤住院患儿的去甲肾上腺素、肾上腺素、多巴胺和/或其酸性代谢产物高香草酸（HVA）和香草扁桃酸（VMA）的尿排泄情况进行回顾性比较，结果显示，HVA的敏感性为72%，特异性为98%；VMA的敏感性为80%，特异性为97%。因此，这两项检测的敏感性和特异性证实了它们在神经母细胞瘤生化诊断中的实用价值，优于去甲肾上腺素、肾上腺素和多巴胺的检测。
