脂联素与两种不同癌症（乳腺癌和结肠癌）之间的关联。
Associations between adiponectin and two different cancers: breast and colon.
作者信息
Gulcelik Mehmet Ali, Colakoglu Kadri, Dincer Halil, Dogan Lutfi, Yenidogan Erdinc, Gulcelik Nese Ersoz
机构信息
General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health, Ankara, Turkey.
出版信息
Asian Pac J Cancer Prev. 2012;13(1):395-8. doi: 10.7314/apjcp.2012.13.1.395.
OBJECTIVES
Breast and colon cancer are neoplasms well known to be related to obesity. Adiponectin, a protein that increases in obesity, seems to be involved in the relationship but clinical data are limited.
METHODS
In this study, we therefore evaluated the serum adiponectin levels in 87 breast and 27 colon cancer patients and assessed the relation with BMI, menopausal status, receptor status and stage of disease.
RESULTS
Serum adiponectin levels were lower in cancer cases (8583 ± 2095 ng/ml for breast cancer, 9513 ± 2276 for colon cancer) than in controls (13905 ± 3263).
CONCLUSION
A low serum adiponectin level may be associated with both breast and colon cancer, and that this association is not statistically significant for either receptor or menopausal status in breast cancer groups.
目的
乳腺癌和结肠癌是众所周知的与肥胖相关的肿瘤。脂联素是一种在肥胖状态下增加的蛋白质，似乎与这种关系有关，但临床数据有限。
方法
因此，在本研究中，我们评估了87例乳腺癌患者和27例结肠癌患者的血清脂联素水平，并评估了其与体重指数、绝经状态、受体状态和疾病分期的关系。
结果
癌症患者的血清脂联素水平（乳腺癌为8583±2095纳克/毫升，结肠癌为9513±2276纳克/毫升）低于对照组（13905±3263纳克/毫升）。
结论
低血清脂联素水平可能与乳腺癌和结肠癌都有关，并且在乳腺癌组中，这种关联在受体或绝经状态方面均无统计学意义。
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