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性染色体非整倍体男性儿童和青少年的社交缺陷：XXY、XYY 和 XXYY 综合征的比较。

Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes.

机构信息

University of Colorado School of Medicine -- Department of Pediatrics 13123 East 16th Ave, B140 Aurora, CO 80045, USA.

出版信息

Res Dev Disabil. 2012 Jul-Aug;33(4):1254-63. doi: 10.1016/j.ridd.2012.02.013. Epub 2012 Mar 23.

DOI:10.1016/j.ridd.2012.02.013
PMID:22502852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3328784/
Abstract

We compare social skills in three groups of males with sex chromosome aneuploidies (SCAs) using the Social Responsiveness Scale (SRS). Participants included males with XXY (N=102, M=10.08 years), XYY (N=40, M=9.93 years), and XXYY (N=32, M=11.57 years). XXY had lower (better) SRS scores compared to XYY and XXYY. Scores were not significantly different between XYY and XXYY. In all groups, there were significantly more with SRS scores in the severe range compared to the SRS normative sample. All groups scored lowest (better) on Social Motivation. Relationships between SRS scores and demographic and clinical variables were examined. Results describe the social skills in males with SCA, and suggest that an additional Y chromosome may contribute to increased risk of autistic behaviors.

摘要

我们使用社交反应量表（SRS）比较了三组性染色体非整倍体（SCA）男性的社交技能。参与者包括 XYYY（N=102，M=10.08 岁）和 XXYY（N=32，M=11.57 岁）。与 XYY 和 XXYY 相比，XXY 的 SRS 评分较低（更好）。XYY 和 XXYY 之间的评分没有显著差异。在所有组中，与 SRS 规范样本相比，有更多的 SRS 评分处于严重范围。所有组在社交动机方面的得分最低（更好）。检查了 SRS 评分与人口统计学和临床变量之间的关系。结果描述了 SCA 男性的社交技能，并表明额外的 Y 染色体可能会增加自闭症行为的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ab/3328784/54eeb239d2f2/nihms366259f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ab/3328784/c64b22cdb819/nihms366259f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ab/3328784/54eeb239d2f2/nihms366259f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ab/3328784/c64b22cdb819/nihms366259f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ab/3328784/54eeb239d2f2/nihms366259f2.jpg

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