Zhao Shuzhi, Li Tao, Zheng Bingqing, Zheng Zhi
Department of Ophthalmology, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China.
Ophthalmic Genet. 2012 Dec;33(4):200-7. doi: 10.3109/13816810.2012.675398. Epub 2012 Apr 17.
To assess the association between the NOS3 4b/a, T-786C and G894T polymorphisms and diabetic retinopathy (DR) susceptibility.
Twenty-one studies covering 8,111 subjects were included. The fixed or random effect model used was based on heterogeneity.
A significant association of the intron 4a allele in the NOS3 4b/a polymorphism with reduced risk of DR was found in dominant (OR 0.778, 95% CI 0.654-0.926) and additive (OR 0.809, 95% CI 0.698-0.937) models. Subgroup analysis revealed that the intron 4a allele additive model (OR 0.807, 95% CI 0.697-0.935) was associated with DR risk in type 2 diabetic patients. We also found a marginally significant association of the C allele in the T-786C polymorphism with reduced risk of proliferative DR. In contrast, no statistically significant association was observed between the G894T polymorphism and DR risk, either in the overall or subgroup analyses.
The intron 4a allele of the 4b/a polymorphism in the eNOS gene has protective effects against DR, especially in type 2 diabetic patients. The C allele of the T-786C polymorphism may be a protective factor for proliferative DR. However, the G894T polymorphism does not appear to influence the development of DR. This conclusion warrants confirmation by further studies.
评估一氧化氮合酶3（NOS3）4b/a、T - 786C和G894T基因多态性与糖尿病视网膜病变（DR）易感性之间的关联。
纳入21项研究，共8111名受试者。根据异质性采用固定效应或随机效应模型。
在显性模型（比值比[OR]0.778，95%可信区间[CI]0.654 - 0.926）和加性模型（OR 0.809，95% CI 0.698 - 0.937）中，发现NOS3 4b/a多态性的内含子4a等位基因与DR风险降低显著相关。亚组分析显示，内含子4a等位基因加性模型（OR 0.807，95% CI 0.697 - 0.935）与2型糖尿病患者的DR风险相关。我们还发现T - 786C多态性的C等位基因与增殖性DR风险降低存在边缘显著关联。相比之下，在总体或亚组分析中，未观察到G894T多态性与DR风险之间存在统计学显著关联。
内皮型一氧化氮合酶（eNOS）基因4b/a多态性的内含子4a等位基因对DR具有保护作用，尤其是在2型糖尿病患者中。T - 786C多态性的C等位基因可能是增殖性DR的保护因素。然而，G894T多态性似乎不影响DR的发生发展。这一结论有待进一步研究证实。
