文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

胶质母细胞瘤的分子和细胞基础的新见解。

Emerging insights into the molecular and cellular basis of glioblastoma.

机构信息

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

出版信息

Genes Dev. 2012 Apr 15;26(8):756-84. doi: 10.1101/gad.187922.112.

DOI:10.1101/gad.187922.112
PMID:22508724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3337451/
Abstract

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.

摘要

胶质母细胞瘤既是最常见的也是最致命的原发性恶性脑肿瘤。广泛的多平台基因组特征分析为这种疾病的分子改变提供了更清晰的图像。这些研究提供了一个新的观点，即“胶质母细胞瘤”代表了几种组织学上相似但分子上不同的疾病，这影响了分类学分类系统、预后和治疗决策。

相似文献

[1]
Emerging insights into the molecular and cellular basis of glioblastoma.

Genes Dev. 2012-4-15

[2]
Genomics illuminates a deadly brain cancer.

JAMA. 2010-3-10

[3]
Genetics of glioblastoma: a window into its imaging and histopathologic variability.

Radiographics. 2011-10

[4]
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features.

Folia Neuropathol. 2012

[5]
[Classification of glioblastoma and genome profiling].

Neurochirurgie. 2010-12

[6]
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.

Proc Natl Acad Sci U S A. 2005-4-19

[7]
Classification of glioblastoma multiforme in adults by molecular genetics.

Cancer J. 2003

[8]
Molecular Subgroups of Glioblastoma- an Assessment by Immunohistochemical Markers.

Pathol Oncol Res. 2019-1

[9]
Transcriptome profiling-based identification of prognostic subtypes and multi-omics signatures of glioblastoma.

Sci Rep. 2019-7-22

[10]
Genomics boosts brain-cancer work.

Nature. 2010-1-21

引用本文的文献

[1]
High expression of SOX9 is a diagnostic and prognostic indicator of glioma.

Front Oncol. 2025-7-7

[2]
CaMKK2 as a therapeutic target to combat metastasis in glioblastoma.

Mol Biol Rep. 2025-7-10

[3]
Cancer/testis antigens FBXO39 and CEP55 expression correlates with survival in GBM patients.

PLoS One. 2025-6-12

[4]
Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance.

Cells. 2025-4-9

[5]
Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma.

J Transl Med. 2025-4-15

[6]
The Co-Expression and Cellular Location of HER Family Members, EGFRvIII, Putative Cancer Stem Cell Biomarkers CD44 and CD109 in Patients with Glioblastoma, and Their Impacts on Prognosis.

Cancers (Basel). 2025-4-4

[7]
Inhibition of glioma cell viability by jatrophone via NF-κB down-regulation and apoptosis inhibitor up-regulation.

Arch Med Sci. 2020-4-15

[8]
Tumor-infiltrating and circulating B cells mediate local and systemic immunomodulatory mechanisms in Glioblastoma.

J Neurooncol. 2025-5

[9]
Dynamic Monitoring of Circulating Tumor DNA to Predict the Risk of Non In Situ Recurrence of Postoperative Glioma: A Prospective Cohort Study.

Cancer Med. 2025-3

[10]
Response Assessment in Long-Term Glioblastoma Survivors Using a Multiparametric MRI-Based Prediction Model.

Brain Sci. 2025-1-31

本文引用的文献

[1]
Girdin maintains the stemness of glioblastoma stem cells.

Oncogene. 2017-6-29

[2]
IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Nature. 2012-2-15

[3]
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Nature. 2012-2-15

[4]
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.

Nature. 2012-2-15

[5]
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.

Proc Natl Acad Sci U S A. 2012-2-8

[6]
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

Nat Genet. 2012-1-29

[7]
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma.

Genes Dev. 2011-12-15

[8]
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

Oncologist. 2011-12-16

[9]
An in vivo patient-derived model of endogenous IDH1-mutant glioma.

Neuro Oncol. 2011-12-13

[10]
Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.

J Exp Med. 2011-12-12

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索