1Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
J Atten Disord. 2014 Feb;18(2):158-68. doi: 10.1177/1087054712440320. Epub 2012 Apr 16.
The goal of this study was to assess the efficacy and tolerability of lis-dexamfetamine dimesylate (LDX) as an adjunct to nicotine replacement therapy in adult smokers with ADHD who were undergoing a quit attempt.
Thirty-two regular adult smokers with ADHD were randomized to receive LDX (n = 17) or placebo (n = 15) in addition to nicotine patch concurrent with a quit attempt.
There were no differences between smokers assigned to LDX versus placebo in any smoking outcomes. Participants treated with LDX demonstrated significant reductions in self-reported and clinician-rated ADHD symptoms. LDX was well tolerated in smokers attempting to quit.
In general, LDX does not facilitate smoking cessation in adults with ADHD more than does placebo, though both groups significantly reduced smoking. LDX demonstrated efficacy for reducing ADHD symptoms in adult smokers engaging in a quit attempt.
本研究旨在评估右苯丙胺 dimesylate(LDX)作为尼古丁替代疗法辅助药物,在尝试戒烟的 ADHD 成年吸烟者中的疗效和耐受性。
32 名患有 ADHD 的成年吸烟者被随机分为 LDX 组(n = 17)或安慰剂组(n = 15),在尝试戒烟期间同时接受尼古丁贴片治疗。
与安慰剂相比,接受 LDX 治疗的吸烟者在任何吸烟结果方面均无差异。接受 LDX 治疗的参与者报告的和临床医生评定的 ADHD 症状均显著减少。LDX 在试图戒烟的吸烟者中耐受性良好。
总的来说,LDX 并没有比安慰剂更能促进 ADHD 成年吸烟者戒烟,尽管两组吸烟者的吸烟量都显著减少。LDX 在患有 ADHD 并试图戒烟的成年吸烟者中显示出对减少 ADHD 症状的疗效。