Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a007930. doi: 10.1101/cshperspect.a007930.
The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling networks. Studies performed in Drosophila over the last 30 years have contributed to our understanding of the role of Wg signaling in the regulation of tissue growth, polarity, and patterning. These studies have revealed mechanisms conserved in the vertebrate Wnt pathways and illustrate the elegance of using the Drosophila model to understand evolutionarily conserved modes of gene regulation. In this article, we describe the function of Wg signaling in patterning the Drosophila embryonic epidermis and wing imaginal disc. As well, we present an overview of the establishment of the Wg morphogen gradient and discuss the differential modes of Wg-regulated gene expression.
无翅(Wg)途径代表了最具特征的细胞间信号网络之一。过去 30 年来在果蝇中进行的研究有助于我们了解 Wg 信号在组织生长、极性和模式形成中的作用。这些研究揭示了在脊椎动物 Wnt 途径中保守的机制,并说明了使用果蝇模型来理解进化上保守的基因调控模式的优雅性。在本文中,我们描述了 Wg 信号在果蝇胚胎表皮和翅膀成虫盘的模式形成中的功能。此外,我们还概述了 Wg 形态发生梯度的建立,并讨论了 Wg 调节基因表达的不同模式。