Department of Vascular Surgery, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Med Hypotheses. 2012 Jul;79(1):71-3. doi: 10.1016/j.mehy.2012.04.003. Epub 2012 Apr 26.
Abdominal Aortic Aneurysms (AAAs) are focal dilation of the aorta that can lead to excessive enlargement and rupture over time. Current practice suggests intervention when the maximum diameter exceeds 5.5 cm, since in this diameter range the annual rupture risk outweighs the operative mortality. However, small AAA (<5.5 cm), though infrequently, may rupture or produce symptoms. Evidence from large randomized studies of small AAAs support the heterogeneity in patterns of growth and rupture potential among small AAAs. Elevated wall stress values have been implicated in AAAs rupture and rapid enlargement. Additionally, many studies have identified a strong correlation between certain geometric factors and elevated stress values. In this article we discuss the possibility that geometrical factors may have a predictive value to identify those small AAAs that have an increased risk of rupture or growth rate either during initial examination or during follow-up, making them amenable for early repair.
腹主动脉瘤(AAA)是主动脉的局灶性扩张,随着时间的推移可能会导致过度增大和破裂。目前的实践建议在最大直径超过 5.5 厘米时进行干预,因为在这个直径范围内,每年的破裂风险超过手术死亡率。然而,小的 AAA(<5.5 厘米),尽管很少见,但可能会破裂或产生症状。来自大型随机小型 AAA 研究的证据支持小型 AAA 中生长和破裂潜力的异质性。壁面应力值的升高与 AAA 的破裂和快速增大有关。此外,许多研究已经确定了某些几何因素与升高的应力值之间存在很强的相关性。在本文中,我们讨论了这样一种可能性,即几何因素可能具有预测价值,可以识别那些在初次检查或随访期间破裂风险或增长率增加的小型 AAA,使其能够早期修复。