健康年轻男性脑中多巴胺转运体与 Tc-99m TRODAT-1 SPECT 结合的可重复性。

Reproducibility of brain dopamine transporter binding with Tc-99m TRODAT-1 SPECT in healthy young men.

机构信息

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.

出版信息

Psychiatry Res. 2012 Mar 31;201(3):222-5. doi: 10.1016/j.pscychresns.2011.07.004. Epub 2012 Apr 30.

DOI:10.1016/j.pscychresns.2011.07.004

Abstract

Single photon emission computed tomography (SPECT) with Tc-99m TRODAT-1 as ligand can be used to evaluate striatal dopamine transporters (DAT) in young subjects. The purpose of this study was to evaluate the reproducibility of (99m)Tc-TRODAT-1 SPECT in DAT binding in healthy young men. Fourteen healthy young men were recruited. The test-retest studies were performed 1week apart. Specific uptake ratios (SUR) of the striatum (ST) and its subregions, the caudate (CA) and the putamen (PU), were measured using the occipital cortex as the reference tissue. The reliability of the two measurements between test and retest, showed significant correlations for the ST, CA and PU, was demonstrated by calculating the intraclass correlation coefficient (ICC). Thus, (99m)Tc-TRODAT-1 SPECT might provide a reproducible and reliable tool in clinical management of young patients with DAT-related disorders.

摘要

使用 Tc-99m TRODAT-1 作为配体的单光子发射计算机断层扫描 (SPECT) 可用于评估年轻受试者的纹状体多巴胺转运体 (DAT)。本研究旨在评估 (99m)Tc-TRODAT-1 SPECT 在健康年轻男性 DAT 结合中的可重复性。招募了 14 名健康的年轻男性。测试-重测研究相隔 1 周进行。使用枕叶皮层作为参考组织测量纹状体 (ST) 及其亚区尾状核 (CA) 和壳核 (PU) 的特异性摄取比 (SUR)。通过计算组内相关系数 (ICC) 来证明两次测量之间的可靠性，即测试和重测之间具有显著相关性。因此，(99m)Tc-TRODAT-1 SPECT 可能为 DAT 相关疾病的年轻患者的临床管理提供一种可重复且可靠的工具。