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肺癌的靶向治疗:新的希望?

Directed therapies in lung cancer: new hope?

机构信息

Servicio de Neumología, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.

出版信息

Arch Bronconeumol. 2012 Oct;48(10):367-71. doi: 10.1016/j.arbres.2012.03.007. Epub 2012 Apr 30.

DOI:10.1016/j.arbres.2012.03.007
PMID:22551924
Abstract

Lung cancer (LC) is a serious health problem due to its high incidence and mortality. Surgery is the most effective therapeutic strategy in this type of tumor, but in recent years new drugs are being investigated that target specific components of the tumor cells, improving survival in patients with advanced disease and relapse. We present a review of individualized treatments in LC, particularly therapies that inhibit epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and anaplastic lymphoma kinase (ALK).

摘要

肺癌(LC)是一个严重的健康问题,由于其高发病率和死亡率。手术是治疗这种肿瘤最有效的策略,但近年来,人们正在研究针对肿瘤细胞特定成分的新药,以改善晚期疾病和复发患者的生存率。我们介绍了 LC 的个体化治疗,特别是抑制表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)和间变性淋巴瘤激酶(ALK)的治疗方法。

相似文献

1
Directed therapies in lung cancer: new hope?肺癌的靶向治疗:新的希望?
Arch Bronconeumol. 2012 Oct;48(10):367-71. doi: 10.1016/j.arbres.2012.03.007. Epub 2012 Apr 30.
2
The emerging role of vascular endothelial growth factor receptor tyrosine kinase inhibitors.血管内皮生长因子受体酪氨酸激酶抑制剂的新作用
Semin Oncol. 2005 Dec;32(6 Suppl 10):S23-9. doi: 10.1053/j.seminoncol.2005.10.005.
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The role of anti-epidermal growth factor receptor and anti-vascular endothelial growth factor therapies in the treatment of non-small-cell lung cancer.表皮生长因子受体和血管内皮生长因子治疗在非小细胞肺癌治疗中的作用。
Clin Lung Cancer. 2010 Mar 1;11(2):82-90. doi: 10.3816/CLC.2010.n.011.
4
[Personalized treatment in non-small cell lung cancer].[非小细胞肺癌的个体化治疗]
Rev Invest Clin. 2012 Jul-Aug;64(4):377-86.
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Targeted therapies in the treatment of advanced non-small-cell lung cancer: update.晚期非小细胞肺癌治疗中的靶向治疗:最新进展
Klin Onkol. 2009;22(4):131-8.
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Update on systemic therapy of advanced non-small-cell lung cancer.晚期非小细胞肺癌全身治疗的最新进展
Expert Rev Anticancer Ther. 2014 Oct;14(10):1189-203. doi: 10.1586/14737140.2014.940327. Epub 2014 Aug 7.
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New targets for non-small-cell lung cancer therapy.非小细胞肺癌治疗的新靶点。
Expert Rev Anticancer Ther. 2007 Oct;7(10):1423-37. doi: 10.1586/14737140.7.10.1423.
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Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC.在非小细胞肺癌治疗中联合使用靶向疗法和多靶点药物。
Oncologist. 2006 Mar;11(3):274-84. doi: 10.1634/theoncologist.11-3-274.
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EGFR-directed therapies to treat non-small-cell lung cancer.表皮生长因子受体靶向治疗非小细胞肺癌。
Expert Opin Investig Drugs. 2009 Aug;18(8):1133-45. doi: 10.1517/13543780903066772.
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Multitargeted inhibitors in lung cancer: new clinical data.肺癌中的多靶点抑制剂:新的临床数据。
Clin Lung Cancer. 2008;9 Suppl 3:S92-9. doi: 10.3816/CLC.2008.s.014.

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Risk Factors for Short-Term Lung Cancer Survival.短期肺癌生存的危险因素。
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Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice.新型氨基色酮衍生物对小鼠肺癌异种移植模型的肿瘤生长具有抑制作用。
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