Regional Department of Eating Disorders, Oslo University Hospital, Oslo, Norway.
Eur Eat Disord Rev. 2012 Sep;20(5):386-92. doi: 10.1002/erv.2179. Epub 2012 May 3.
This paper aims to study long-term bone mineral development in former patients with an onset of anorexia nervosa during childhood and adolescence.
Bone mineral density (BMD) in lumbar spine and total hip was measured in 39 female participants (mean age = 23.1 years, SD 3.5) an average of 8.1 (±3.3) years after treatment start.
At follow-up, seven participants (17.9%) still suffered from an eating disorder. Mean BMD in the former patients was within the normal range in the hip but significantly reduced in the spine. Fourteen (36%) of the participants had osteopenia, and three (8%) had osteoporosis in the spine and/or hip. Amenorrhea for more than two years was associated with reduced BMD in the spine, whereas low weight at follow-up was associated with low BMD in both the spine and the hip.
A large minority of these former patients had low bone mass in young adulthood. In accordance with other studies, our findings support the importance of weight restoration for future bone health in young patients with anorexia nervosa.
本研究旨在探讨儿童和青少年时期发病的厌食症患者长期的骨矿物质发育情况。
39 名女性参与者（平均年龄=23.1 岁，标准差=3.5）在治疗开始平均 8.1（±3.3）年后，测量其腰椎和全髋关节的骨矿物质密度（BMD）。
随访时，仍有 7 名（17.9%）参与者患有饮食障碍。与髋关节相比，前患者的平均 BMD 仍在正常范围内，但脊柱的 BMD 明显降低。14 名（36%）参与者存在骨质疏松症，3 名（8%）参与者存在脊柱和/或髋关节的骨质疏松症。闭经超过两年与脊柱 BMD 降低有关，而随访时体重较低与脊柱和髋关节的 BMD 降低均有关。
这些前患者中有很大一部分在成年早期骨量较低。与其他研究一致，我们的研究结果支持在患有厌食症的年轻患者中，体重恢复对未来骨骼健康的重要性。
