Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724, United States.
Semin Immunol. 2012 Oct;24(5):356-64. doi: 10.1016/j.smim.2012.04.009. Epub 2012 May 1.
Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.
研究表明，在动物模型和人类研究中，对各种病原体的疫苗接种或感染的 CD8 T 细胞反应存在明显的与年龄相关的缺陷。总的来说，最近的研究表明，衰老的 CD8 T 细胞反应的强度降低，并且向效应细胞分化不良，效应功能的储备减少。在这里，我们综述了这些缺陷的潜在机制。我们特别针对幼稚 CD8 T 细胞前体库的表型和数量变化、持续病毒感染和炎症的影响以及这些细胞被激活的老化环境的贡献进行了讨论。
