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阿尔茨海默病脉络丛的病理改变：对新治疗方法的启示

Pathological alteration in the choroid plexus of Alzheimer's disease: implication for new therapy approaches.

作者信息

Krzyzanowska Agnieszka, Carro Eva

机构信息

Neuroscience Group, Instituto de Investigacion Hospital 12 de Octubre (i+12) Madrid, Spain.

出版信息

Front Pharmacol. 2012 May 3;3:75. doi: 10.3389/fphar.2012.00075. eCollection 2012.

DOI:10.3389/fphar.2012.00075
PMID:22563316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3342675/
Abstract

Morphological alterations of choroid plexus in Alzheimer's disease (AD) have been extensively investigated. These changes include epithelial atrophy, thickening of the basement membrane, and stroma fibrosis. As a result, synthesis, secretory, and transportation functions are significantly altered resulting in decreased cerebrospinal fluid (CSF) turnover. Recent studies discuss the potential impacts of these changes, including the possibility of reduced resistance to stress insults and slow clearance of toxic compounds from CSF with specific reference to the amyloid peptide. Here, we review new evidences for AD-related changes in the choroid plexus. The data suggest that the significantly altered functions of the choroid plexus contribute to the multiparametric pathogenesis of late-onset AD.

摘要

阿尔茨海默病（AD）脉络丛的形态学改变已得到广泛研究。这些变化包括上皮萎缩、基底膜增厚和间质纤维化。因此，合成、分泌和运输功能显著改变，导致脑脊液（CSF）周转率降低。最近的研究讨论了这些变化的潜在影响，包括对应激损伤的抵抗力降低以及脑脊液中有毒化合物（特别是淀粉样肽）清除缓慢的可能性。在这里，我们综述了脉络丛中与AD相关变化的新证据。数据表明，脉络丛功能的显著改变促成了晚发性AD的多参数发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e48/3342675/92bee0b60210/fphar-03-00075-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e48/3342675/7801c6e0fb5f/fphar-03-00075-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e48/3342675/92bee0b60210/fphar-03-00075-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e48/3342675/7801c6e0fb5f/fphar-03-00075-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e48/3342675/92bee0b60210/fphar-03-00075-g002.jpg

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