内毒素吸入可改变新生小鼠的肺发育。
Endotoxin inhalation alters lung development in neonatal mice.
机构信息
Department of Occupational and Environmental Health, University of Iowa, Iowa City, 52242, USA.
出版信息
Am J Ind Med. 2012 Dec;55(12):1146-58. doi: 10.1002/ajim.22061. Epub 2012 May 10.
BACKGROUND
Childhood asthma is a significant public health problem. Epidemiologic evidence suggests an association between childhood asthma exacerbations and early life exposure to environmental endotoxin. Although the pathogenesis of endotoxin-induced adult asthma is well studied, questions remain about the impact of environmental endotoxin on pulmonary responsiveness in early life.
METHODS
We developed a murine model of neonatal/juvenile endotoxin exposures approximating those in young children and evaluated the lungs inflammatory and remodeling responses.
RESULTS
Persistent lung inflammation induced by the inhalation of endotoxin in early life was demonstrated by the influx of inflammatory cells and pro-inflammatory mediators to the airways and resulted in abnormal alveolarization.
CONCLUSIONS
Results of this study advance the understanding of the impact early life endotoxin inhalation has on the lower airways, and demonstrates the importance of an experimental design that approximates environmental exposures as they occur in young children.
背景
儿童哮喘是一个重大的公共卫生问题。流行病学证据表明，儿童哮喘发作与生命早期暴露于环境内毒素之间存在关联。尽管内毒素诱导的成人哮喘的发病机制已经得到很好的研究，但关于环境内毒素对生命早期肺部反应性的影响仍存在疑问。
方法
我们建立了一种模拟幼儿时期内毒素暴露的新生/幼年小鼠模型，并评估了肺部炎症和重塑反应。
结果
早期生活中吸入内毒素引起的持续肺部炎症，表现为炎症细胞和促炎介质向气道的浸润，导致肺泡异常。
结论
这项研究的结果增进了对内毒素吸入对下呼吸道影响的理解，并表明了一种实验设计的重要性，这种设计模拟了幼儿时期环境暴露的情况。
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