[通过生化介质对骨折修复进行实验性加速（作者译）]

[Experimental acceleration of fracture repair by biochemical media (author's transl)].

作者信息

Bethge J F, Babayan R, Borm H P, von Fehrentheil R, ten Hoff H, Hose H, Mangels P, Piening H, Reimers C, Wider U

出版信息

Res Exp Med (Berl). 1979 Jul 20;175(3):197-222. doi: 10.1007/BF01851277.

Abstract

The influence of calcitonine, amino acids, ribonucleid acids, kallikrein, growth hormone, and cyclic adenosine 3'5' monophosphate on fracture repair was tested in rabbits. To obtain an objective measurement of callus stability the bones were bent mechanically. The force applied and the degree of bending were recorded continuously. The slope of the curve was taken as a parameter of callus stability. In the series with calcitonine no influence on fracture healing was found. Injections of ribonucleic acids, amino acids, kallidrein, and growth hormone demonstrated a limited effect on bone repair. Callus formation was stimulated by adenosine 3'5' monophosphate. Optimal results were achieved by a combination of adenosine 3'5' monophosphate, amino acids, ribonucleic acids, and kallikrein.

摘要

在兔子身上测试了降钙素、氨基酸、核糖核酸、激肽释放酶、生长激素和环磷酸腺苷对骨折修复的影响。为了客观测量骨痂稳定性，对骨骼进行了机械弯曲。持续记录施加的力和弯曲程度。曲线的斜率被用作骨痂稳定性的参数。在使用降钙素的系列实验中，未发现对骨折愈合有影响。注射核糖核酸、氨基酸、激肽释放酶和生长激素对骨修复显示出有限的效果。环磷酸腺苷刺激了骨痂形成。通过联合使用环磷酸腺苷、氨基酸、核糖核酸和激肽释放酶取得了最佳效果。