一种来自绒毛地胆草的新型倍半萜内酯。

A new sesquiterpene lactone from Elephantopus tomentosus.

作者信息

Wang Bei, Mei Wen-Li, Zeng Yan-Bo, Guo Zhi-Kai, Liu Guo-Dao, Dai Hao-Fu

机构信息

Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.

出版信息

J Asian Nat Prod Res. 2012;14(7):700-3. doi: 10.1080/10286020.2012.682153. Epub 2012 May 15.

DOI:10.1080/10286020.2012.682153

PMID:22582752

Abstract

A new sesquiterpene lactone, named tomenphantopin H (1), together with two known germacranolides, 2β-methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate (2) and 2-deethoxy-2-hydroxyphantomolin (3), was isolated from the whole plant of Elephantopus tomentosus Linn. The new compound was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, and HMBC) and HR-ESI-MS analyses. All compounds exhibited antibacterial activity.

摘要

从绒毛地胆草（Elephantopus tomentosus Linn.）的全株中分离出一种新的倍半萜内酯，命名为绒毛地胆草素H（1），以及两种已知的吉马烷型倍半萜内酯，2β-甲氧基-2-去乙氧基-8-O-去酰基地胆草醇-8-O-惕各酸酯（2）和2-去乙氧基-2-羟基地胆草醇（3）。通过结合一维和二维核磁共振技术（COSY、HMQC和HMBC）以及高分辨电喷雾电离质谱分析，对新化合物进行了全面的结构解析。所有化合物均表现出抗菌活性。