重症加强护理病房患者经鼻胃管给予泊沙康唑的血浆浓度。
Plasma concentrations of posaconazole administered via nasogastric tube in patients in a surgical intensive care unit.
机构信息
Pharmacy Department, University Hospital of Heidelberg, Heidelberg, Germany.
出版信息
Antimicrob Agents Chemother. 2012 Aug;56(8):4468-70. doi: 10.1128/AAC.06167-11. Epub 2012 May 14.
Abstract
Abdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients, possibly due to poor absorption.
摘要
腹部手术可能会影响肠道吸收和泊沙康唑在血液中的水平。我们测量了外科重症监护病房（SICU）患者的泊沙康唑血浆水平，并尝试建立预测群体药代动力学模型。通过高效液相色谱法（HPLC）测量了 15 名接受泊沙康唑经鼻胃管给药的患者的 270 个样本。与血液科患者相比，SICU 患者的血浆药物浓度较低，表观清除率较高，分布容积较高，可能是由于吸收不良所致。
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