地舒单抗治疗后的骨 Paget 病：病例报告。
Paget's disease of the bone after treatment with Denosumab: a case report.
机构信息
Research Center of Ageing and Osteoporosis, Department of Medicine, Glostrup University Hospital, 2600 Glostrup, Denmark.
出版信息
Bone. 2012 May;50(5):1023-5. doi: 10.1016/j.bone.2012.01.020.
Bone affection in Paget's disease is characterized by increased bone turnover localised at one or more sites of the skeleton. Bisphosphonates are the drugs of choice when treating the increased bone turnover in Paget's disease. However, in cases of decreased kidney function only less effective treatments that are available as bisphosphonates are contraindicated in these patients. We present a case of a male patient aged 86 years with GFR of 11 mL/min and Paget's disease successfully treated by Denosumab. The bone turnover and pain decreased upon treatment.
Paget 病的骨骼病变特征为一处或多处骨骼的骨转换增加。当治疗 Paget 病的骨转换增加时，双膦酸盐是首选药物。然而，在肾功能下降的情况下，只有作用较弱的双膦酸盐治疗药物对这些患者禁忌使用。我们报告了一例 GFR 为 11 mL/min 的 86 岁男性患者，成功接受地舒单抗治疗 Paget 病。治疗后骨转换和疼痛均降低。
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