Nayyatip Sanchai, Thaichana Pak, Buayairaksa Mongkol, Tuntiwechapikul Wirote, Meepowpan Puttinan, Nuntasaen Narong, Pompimon Wilart
Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand.
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand.
Int J Mol Sci. 2012;13(4):5010-5018. doi: 10.3390/ijms13045010. Epub 2012 Apr 20.
A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively.
从内托果木中分离出一种新的马兜铃内酰胺,命名为内托果木酰胺-III(10-氨基-2,3,4,6-四甲氧基菲-1-羧酸内酰胺,1)以及已知生物碱豆甾烷醇内酰胺(2)。根据它们的光谱数据解释阐明了其结构。化合物1和2对人结肠腺癌(HCT15)细胞系表现出显著的细胞毒性,IC50值分别为1.68和1.32μM。