Miles Edward F, Jacimore Laura L, Nelson John W
Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA.
Case Rep Oncol Med. 2011;2011:864371. doi: 10.1155/2011/864371. Epub 2011 Sep 15.
Anal canal cancer is rare, accounting for only 1.3% of all gastrointestinal tract malignancies. Prostate cancer incidence is much higher and accounts for 27.6% of all malignancies in men. Treatment guidelines for anal cancer involve radiotherapy to the primary site and draining lymphatics while treatment for prostate cancer can also include pelvic radiotherapy. The literature is silent on the optimum course of action when these two malignancies are found synchronously or metachronously. Herein, we report a case of a patient diagnosed with intermediate risk prostate cancer who, prior to definitive therapy for this first malignancy, was also diagnosed with anal canal cancer. We conclude that a simultaneous approach with radiation therapy and chemotherapy with subsequent boost to the prostate is recommended. Screening for synchronous prostate cancer in male anal canal cancer patients is probably indicated and may preclude suboptimal treatment for a second occult primary.
肛管癌较为罕见，仅占所有胃肠道恶性肿瘤的1.3%。前列腺癌的发病率则高得多，占男性所有恶性肿瘤的27.6%。肛管癌的治疗指南包括对原发部位和引流淋巴管进行放射治疗，而前列腺癌的治疗也可包括盆腔放疗。当这两种恶性肿瘤同时或异时发现时，关于最佳治疗方案的文献尚无定论。在此，我们报告一例被诊断为中度风险前列腺癌的患者，在对这第一种恶性肿瘤进行确定性治疗之前，还被诊断出患有肛管癌。我们得出结论，建议采用放疗和化疗同时进行，随后对前列腺进行强化治疗的方法。男性肛管癌患者可能需要筛查同步性前列腺癌，这可能避免对第二个隐匿性原发肿瘤进行次优治疗。
