RYR3 基因多态性与 HIV 感染白种人 cIMT 的复制关联。
Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites.
机构信息
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
出版信息
AIDS. 2012 Jul 31;26(12):1571-3. doi: 10.1097/QAD.0b013e328355359f.
Abstract
To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
摘要
为了复制 RYR3 基因变异与动脉粥样硬化的替代标志物——颈总动脉内膜中层厚度（cIMT）之间的关联，我们对 244 名 HIV 阳性和 HIV 阴性男性的亚群进行了单核苷酸多态性（SNP）rs2229116 和 rs7177922 的基因分型。在调整年龄和使用司他夫定（d4T）后，SNP rs2229116 与感染 HIV 的白人男性的常见 cIMT 相关。这种关联在较年轻的个体中更为明显，而在年龄较大的个体中则减少。
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