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[急性尼卡地平与硝苯地平中毒。多中心研究。法国毒物控制中心与ARIT的合作研究]

[Acute nicardipine and nifedipine poisoning. Multicenter study. Cooperative study by the french poison control centers and the ARIT].

作者信息

Droy J M, Daridon E, Leroy J, Massari P

机构信息

Hôpital Charles Nicolles, Rouen.

出版信息

J Toxicol Clin Exp. 1990 Jul-Aug;10(4):249-56.

PMID:2262920
Abstract

A study, that was realized by the French Association of Poison Control Centers, tried to estimate the toxicity of Dihydropyridine derivatives towards human beings, in comparison with other calcium antagonists, said to be more toxic. Though, the toxicity of the Dihydropyridine derivatives happens to be far less important considering the rarity or absence of their cardiac effects, it must not however be underestimated in the case of a mass ingestion, or if they are taken simultaneously with psychotropic or cardiotropic drugs.

摘要

法国毒物控制中心协会开展了一项研究,试图评估二氢吡啶衍生物对人类的毒性,并与其他据称毒性更强的钙拮抗剂进行比较。尽管考虑到二氢吡啶衍生物心脏效应的罕见性或不存在,其毒性相对较小,但在大量摄入或与精神药物或心脏药物同时服用的情况下,其毒性也不可低估。

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