BDNF-270C>T 多态性可能与脑卒中类型有关，BDNF-196G>A 与出血性脑卒中的早期神经功能缺损相对应。
BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke.
机构信息
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland.
出版信息
J Neuroimmunol. 2012 Aug 15;249(1-2):71-5. doi: 10.1016/j.jneuroim.2012.04.011. Epub 2012 May 24.
Genetic factors might be involved in stroke prognosis, however the role of brain-derived neurotrophic factor (BDNF) in stroke recovery is unknown. We have studied BDNF -196 G>A and -270 C>T polymorphisms in ischemic and hemorrhagic stroke and their impact on stroke prognosis. There was higher occurrence of BDNF -270 CC genotype in patients with hemorrhagic than ischemic stroke (96% versus 86%, p=0.0495). In hemorrhagic stroke BDNF -196 GG carriers scored better in NIHSS at admission (14.23 versus 21.00, p=0.0192) and after 7days (8.60 versus 15.00, p=0.0408) of onsets. None of the determined polymorphisms had any impact on 30-day early outcome in ischemic and hemorrhagic stroke.
遗传因素可能与中风预后相关，但脑源性神经营养因子（BDNF）在中风恢复中的作用尚不清楚。我们研究了 BDNF-196 G>A 和-270 C>T 多态性在缺血性和出血性中风中的作用及其对中风预后的影响。与缺血性中风相比，出血性中风患者 BDNF-270 CC 基因型的发生率更高（96%比 86%，p=0.0495）。在出血性中风中，BDNF-196 GG 携带者在入院时 NIHSS 评分更高（14.23 比 21.00，p=0.0192），在发病后 7 天时更高（8.60 比 15.00，p=0.0408）。在缺血性和出血性中风中，所确定的多态性均未对 30 天早期预后产生任何影响。
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