脊柱关节炎患者肾脏、心脏、肺部及神经关节外临床表现的低患病率：巴西脊柱关节炎注册研究分析

Low prevalence of renal, cardiac, pulmonary, and neurological extra-articular clinical manifestations in spondyloarthritis: analysis of the Brazilian Registry of Spondyloarthritis.

作者信息

Rodrigues Carlos Ewerton Maia, Vieira Walber Pinto, Bortoluzzo Adriana B, Gonçalves Célio Roberto, da Silva José Antonio Braga, Ximenes Antonio Carlos, Bértolo Manoel B, Ribeiro Sandra L E, Keiserman Mauro, Menin Rita, Skare Thelma L, Carneiro Sueli, Azevedo Valderílio F, Albuquerque Elisa N, Bianchi Washington A, Bonfiglioli Rubens, Campanholo Cristiano, Carvalho Hellen M S, Costa Izaias P, Duarte Angela P, Kohem Charles L, Leite Nocy H, Lima Sonia A L, Meirelles Eduardo S, Pereira Ivânio A, Pinheiro Marcelo M, Polito Elizandra, Resende Gustavo G, Rocha Francisco Airton C, Santiago Mittermayer B, Sauma Maria de Fátima L C, Valim Valeria, Sampaio-Barros Percival D

机构信息

Universidade de Fortaleza.

出版信息

Rev Bras Reumatol. 2012 May-Jun;52(3):375-83.

PMID:22641592

Abstract

OBJECTIVE

To describe the extra-articular manifestations (cardiac, renal, pulmonary, and neurological), usually not related to spondyloarthritis (SpA), in a large cohort of Brazilian patients.

MATERIALS AND METHODS

This retrospective study analyzed 1,472 patients diagnosed with SpA and cared for at 29 health care centers distributed in the five major geographic regions in the country, participating in the Brazilian Registry of Spondyloarthritis (BRS). All patients were assessed for the prevalence of major extra-articular manifestations (cardiac, renal, pulmonary, and neurological), classified according to the diagnosis [ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease (IBD), undifferentiated spondyloarthritis (uSpA), and juvenile SpA], and according to the clinical presentation (axial, peripheral, mixed, and enthesitis).

RESULTS

Of the patients with SpA assessed, 963 had AS, 271 PsA, 49 ReA, 48 arthritis associated with IBD, 98 uSpA, and 43 juvenile SpA. Cardiac involvement was reported in 44 patients (3.0%), pulmonary involvement in 19 (1.3%), renal involvement in 17 (1.2%), and neurological involvement in 13 patients (0.9%). Most patients with visceral involvement had AS or PsA, and the mixed (axial + peripheral) and/or predominantly axial clinical form.

CONCLUSION

Cardiac, renal, pulmonary, and neurological extra-articular manifestations are quite infrequent in SpA, ranging from 0.9% to 3% in this large Brazilian cohort, and affected predominantly patients with AS and PsA.

摘要

目的

描述一大群巴西患者中通常与脊柱关节炎（SpA）无关的关节外表现（心脏、肾脏、肺部和神经方面）。

材料与方法

这项回顾性研究分析了1472例被诊断为SpA并在分布于该国五个主要地理区域的29个医疗中心接受治疗的患者，这些患者参与了巴西脊柱关节炎登记处（BRS）。所有患者均评估了主要关节外表现（心脏、肾脏、肺部和神经方面）的患病率，并根据诊断[强直性脊柱炎（AS）、银屑病关节炎（PsA）、反应性关节炎（ReA）、与炎症性肠病（IBD）相关的关节炎、未分化脊柱关节炎（uSpA）和幼年SpA]以及临床表现（轴向、外周、混合和附着点炎）进行分类。

结果

在接受评估的SpA患者中，963例患有AS，271例患有PsA，49例患有ReA，48例患有与IBD相关的关节炎，98例患有uSpA，43例患有幼年SpA。报告有心脏受累的患者有44例（3.0%），肺部受累的有19例（1.3%），肾脏受累的有17例（1.2%），神经受累的有13例（0.9%）。大多数有内脏受累的患者患有AS或PsA，且为混合（轴向+外周）和/或主要为轴向的临床类型。