关于：线粒体生理学与医学SGP研讨会——LETM1的病理生理学的观点 - Suppr

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

作者信息

Nowikovsky Karin, Pozzan Tullio, Rizzuto Rosario, Scorrano Luca, Bernardi Paolo

机构信息

Department of Internal Medicine 1, Anna Spiegel Center of Translational Research, Medical University Vienna, 1090 Wien, Austria.

出版信息

J Gen Physiol. 2012 Jun;139(6):445-54. doi: 10.1085/jgp.201110757.

DOI:10.1085/jgp.201110757

PMID:22641639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362517/

Abstract

摘要

相似文献

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

J Gen Physiol. 2012 Jun;139(6):445-54. doi: 10.1085/jgp.201110757.

LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?

Trends Biochem Sci. 2019 Aug;44(8):648-658. doi: 10.1016/j.tibs.2019.04.002. Epub 2019 May 14.

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

J Gen Physiol. 2014 Jan;143(1):67-73. doi: 10.1085/jgp.201311096. Epub 2013 Dec 16.

Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.

Science. 2009 Oct 2;326(5949):144-7. doi: 10.1126/science.1175145.

Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins.

Biochim Biophys Acta. 2005 Jun 1;1711(1):41-8. doi: 10.1016/j.bbamem.2005.02.018. Epub 2005 Mar 22.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

Cell biology. A revolving door for calcium.

Science. 2009 Oct 2;326(5949):57-8. doi: 10.1126/science.1180482.

The destiny of Ca(2+) released by mitochondria.

J Physiol Sci. 2015 Jan;65(1):11-24. doi: 10.1007/s12576-014-0326-7. Epub 2014 Jul 4.

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

FASEB J. 2014 Nov;28(11):4936-49. doi: 10.1096/fj.14-256453. Epub 2014 Jul 30.

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2249-54. doi: 10.1073/pnas.1308558110. Epub 2013 May 28.

引用本文的文献

Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease.

Nat Cardiovasc Res. 2024 May;3(5):500-514. doi: 10.1038/s44161-024-00463-7. Epub 2024 May 1.

TMBIM5 is the Ca /H antiporter of mammalian mitochondria.

EMBO Rep. 2022 Dec 6;23(12):e54978. doi: 10.15252/embr.202254978. Epub 2022 Nov 2.

Biochemical properties of H-Ca-exchanger in the myometrium mitochondria.

Curr Res Physiol. 2022 Sep 21;5:369-380. doi: 10.1016/j.crphys.2022.09.005. eCollection 2022.

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement.

Am J Hum Genet. 2022 Sep 1;109(9):1692-1712. doi: 10.1016/j.ajhg.2022.07.007.

Mitochondrial Calcium: Effects of Its Imbalance in Disease.

Antioxidants (Basel). 2022 Apr 20;11(5):801. doi: 10.3390/antiox11050801.

Mitochondrial calcium exchange in physiology and disease.

Physiol Rev. 2022 Apr 1;102(2):893-992. doi: 10.1152/physrev.00041.2020. Epub 2021 Oct 26.

Mitochondrial Ca Signaling in Health, Disease and Therapy.

Cells. 2021 May 25;10(6):1317. doi: 10.3390/cells10061317.

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling.

Front Physiol. 2021 Mar 18;12:637852. doi: 10.3389/fphys.2021.637852. eCollection 2021.

Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics.

Mitochondrion. 2021 Mar;57:9-22. doi: 10.1016/j.mito.2020.12.001. Epub 2020 Dec 11.

Physiological Ca Transients Versus Pathological Steady-State Ca Elevation, Who Flips the ROS Coin in Skeletal Muscle Mitochondria.

Front Physiol. 2020 Oct 22;11:595800. doi: 10.3389/fphys.2020.595800. eCollection 2020.

本文引用的文献

Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes.

J Cell Sci. 2012 Feb 1;125(Pt 3):625-33. doi: 10.1242/jcs.090126. Epub 2012 Feb 13.

Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster.

J Biol Chem. 2011 Dec 2;286(48):41163-41170. doi: 10.1074/jbc.M111.268375. Epub 2011 Oct 7.

After half a century mitochondrial calcium in- and efflux machineries reveal themselves.

EMBO J. 2011 Sep 20;30(20):4119-25. doi: 10.1038/emboj.2011.337.

Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.

Traffic. 2011 Oct;12(10):1457-66. doi: 10.1111/j.1600-0854.2011.01239.x. Epub 2011 Jul 22.

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Nature. 2011 Jun 19;476(7360):336-40. doi: 10.1038/nature10230.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.

Metabolic disorders of fetal life: glycogenoses and mitochondrial defects of the mitochondrial respiratory chain.

Semin Fetal Neonatal Med. 2011 Aug;16(4):181-9. doi: 10.1016/j.siny.2011.04.010. Epub 2011 May 28.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons.

Eur J Neurosci. 2011 Mar;33(5):831-42. doi: 10.1111/j.1460-9568.2010.07576.x. Epub 2011 Jan 24.

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

J Clin Invest. 2010 Oct;120(10):3680-7. doi: 10.1172/JCI43171. Epub 2010 Sep 20.

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Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

作者信息

Nowikovsky Karin, Pozzan Tullio, Rizzuto Rosario, Scorrano Luca, Bernardi Paolo

机构信息

Department of Internal Medicine 1, Anna Spiegel Center of Translational Research, Medical University Vienna, 1090 Wien, Austria.

出版信息

J Gen Physiol. 2012 Jun;139(6):445-54. doi: 10.1085/jgp.201110757.

DOI:10.1085/jgp.201110757

PMID:22641639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362517/

Abstract

摘要

相似文献

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

J Gen Physiol. 2012 Jun;139(6):445-54. doi: 10.1085/jgp.201110757.

LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?

Trends Biochem Sci. 2019 Aug;44(8):648-658. doi: 10.1016/j.tibs.2019.04.002. Epub 2019 May 14.

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

J Gen Physiol. 2014 Jan;143(1):67-73. doi: 10.1085/jgp.201311096. Epub 2013 Dec 16.

Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.

Science. 2009 Oct 2;326(5949):144-7. doi: 10.1126/science.1175145.

Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins.

Biochim Biophys Acta. 2005 Jun 1;1711(1):41-8. doi: 10.1016/j.bbamem.2005.02.018. Epub 2005 Mar 22.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

Cell biology. A revolving door for calcium.

Science. 2009 Oct 2;326(5949):57-8. doi: 10.1126/science.1180482.

The destiny of Ca(2+) released by mitochondria.

J Physiol Sci. 2015 Jan;65(1):11-24. doi: 10.1007/s12576-014-0326-7. Epub 2014 Jul 4.

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

FASEB J. 2014 Nov;28(11):4936-49. doi: 10.1096/fj.14-256453. Epub 2014 Jul 30.

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2249-54. doi: 10.1073/pnas.1308558110. Epub 2013 May 28.

引用本文的文献

Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease.

Nat Cardiovasc Res. 2024 May;3(5):500-514. doi: 10.1038/s44161-024-00463-7. Epub 2024 May 1.

TMBIM5 is the Ca /H antiporter of mammalian mitochondria.

EMBO Rep. 2022 Dec 6;23(12):e54978. doi: 10.15252/embr.202254978. Epub 2022 Nov 2.

Biochemical properties of H-Ca-exchanger in the myometrium mitochondria.

Curr Res Physiol. 2022 Sep 21;5:369-380. doi: 10.1016/j.crphys.2022.09.005. eCollection 2022.

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement.

Am J Hum Genet. 2022 Sep 1;109(9):1692-1712. doi: 10.1016/j.ajhg.2022.07.007.

Mitochondrial Calcium: Effects of Its Imbalance in Disease.

Antioxidants (Basel). 2022 Apr 20;11(5):801. doi: 10.3390/antiox11050801.

Mitochondrial calcium exchange in physiology and disease.

Physiol Rev. 2022 Apr 1;102(2):893-992. doi: 10.1152/physrev.00041.2020. Epub 2021 Oct 26.

Mitochondrial Ca Signaling in Health, Disease and Therapy.

Cells. 2021 May 25;10(6):1317. doi: 10.3390/cells10061317.

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling.

Front Physiol. 2021 Mar 18;12:637852. doi: 10.3389/fphys.2021.637852. eCollection 2021.

Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics.

Mitochondrion. 2021 Mar;57:9-22. doi: 10.1016/j.mito.2020.12.001. Epub 2020 Dec 11.

Physiological Ca Transients Versus Pathological Steady-State Ca Elevation, Who Flips the ROS Coin in Skeletal Muscle Mitochondria.

Front Physiol. 2020 Oct 22;11:595800. doi: 10.3389/fphys.2020.595800. eCollection 2020.

本文引用的文献

Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes.

J Cell Sci. 2012 Feb 1;125(Pt 3):625-33. doi: 10.1242/jcs.090126. Epub 2012 Feb 13.

Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster.

J Biol Chem. 2011 Dec 2;286(48):41163-41170. doi: 10.1074/jbc.M111.268375. Epub 2011 Oct 7.

After half a century mitochondrial calcium in- and efflux machineries reveal themselves.

EMBO J. 2011 Sep 20;30(20):4119-25. doi: 10.1038/emboj.2011.337.

Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.

Traffic. 2011 Oct;12(10):1457-66. doi: 10.1111/j.1600-0854.2011.01239.x. Epub 2011 Jul 22.

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Nature. 2011 Jun 19;476(7360):336-40. doi: 10.1038/nature10230.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.

Metabolic disorders of fetal life: glycogenoses and mitochondrial defects of the mitochondrial respiratory chain.

Semin Fetal Neonatal Med. 2011 Aug;16(4):181-9. doi: 10.1016/j.siny.2011.04.010. Epub 2011 May 28.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons.

Eur J Neurosci. 2011 Mar;33(5):831-42. doi: 10.1111/j.1460-9568.2010.07576.x. Epub 2011 Jan 24.

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

J Clin Invest. 2010 Oct;120(10):3680-7. doi: 10.1172/JCI43171. Epub 2010 Sep 20.

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

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Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

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