Department of Psychiatry, University of Birmingham, Birmingham, UK.
Early Interv Psychiatry. 2009 Nov;3(4):296-9. doi: 10.1111/j.1751-7893.2009.00141.x.
Despite remission being the primary objective following the first episode of schizophrenia, clinically stabilized patients nevertheless relapse.
To assess the extent and fluctuation of low-level psychotic symptoms in patients who are in remission after first-episode schizophrenia and consider whether this is equivalent to symptomatology experienced by those at 'ultra high risk' (UHR) of developing first-episode psychosis.
We examined the phenomenological characteristics of 11 patients who fulfilled international remission criteria using the Structured Interview for Prodromal Symptoms and compared this cohort with an UHR sample.
Remitted patients were experiencing attenuated positive symptoms (73%) and brief limited intermittent psychotic symptoms (18%), features that were similarly prevalent in the UHR group. There was no significant fluctuation in these low-level symptoms over the course of four interviews.
Although further research is required in this novel field, such features could form the building blocks for better prediction of psychotic relapse.
尽管精神分裂症首次发作后缓解是主要目标，但临床稳定的患者仍会复发。
评估首次精神分裂症缓解后患者低度精神病症状的程度和波动，并考虑这是否等同于处于发展为首发精神病超高风险（UHR）人群的症状。
我们使用前驱症状结构化访谈检查了 11 名符合国际缓解标准的患者的现象学特征，并将该队列与 UHR 样本进行了比较。
缓解期患者经历了轻度阳性症状（73%）和短暂有限间歇性精神病症状（18%），这些特征在 UHR 组中同样普遍存在。这些低度症状在四次访谈过程中没有明显波动。
尽管在这个新领域还需要进一步研究，但这些特征可能为更好地预测精神病复发奠定基础。
