母鼠在与幼崽自发性接触期间前额皮质神经元的放电模式。
Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups.
机构信息
Department of Psychiatry, The McKnight Brain Institute, University of Florida, P.O. Box 100256, Gainesville, FL 32610, USA.
出版信息
Brain Res Bull. 2012 Aug 1;88(5):534-42. doi: 10.1016/j.brainresbull.2012.05.012. Epub 2012 May 27.
Abstract
Extracellular single unit activity was recorded from medial prefrontal cortex (mPFC) of postpartum dams over the course of 3 days while they engaged in spontaneous pup-directed behaviors and non-specific exploratory behavior. Out of 109 units identified over the course of the experiment, 15 units were observed to be pup-responsive and 15 increased their discharge rates non-specifically while not attending to pups. An association between neuronal activity and typical maternal behaviors (e.g., retrieval, pup-grooming, nursing) was not observed. Instead, brief bouts of snout contact with pups were accompanied by phasic increases and decreases in spike rates. The observed pup contact responsive cells might play a role in processing of sensory feedback from pups or the transmission of modulatory output to other subcortical maternal brain areas.
摘要
在产后母鼠进行自发的幼鼠导向行为和非特定的探索行为的过程中，记录了其内侧前额叶皮层（mPFC）的细胞外单单位活动。在实验过程中鉴定出的 109 个单位中，有 15 个单位对幼鼠有反应，有 15 个单位在不关注幼鼠时非特异性地增加了放电率。神经元活动与典型的母性行为（例如，检索、幼鼠梳理、哺乳）之间没有观察到关联。相反，与幼鼠短暂的口鼻接触伴随着尖峰率的阶段性增加和减少。观察到的幼鼠接触反应细胞可能在处理来自幼鼠的感觉反馈或调节输出到其他皮质下母鼠脑区的过程中发挥作用。
相似文献
1
Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups.母鼠在与幼崽自发性接触期间前额皮质神经元的放电模式。
Brain Res Bull. 2012 Aug 1;88(5):534-42. doi: 10.1016/j.brainresbull.2012.05.012. Epub 2012 May 27.
2
Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats.内侧前额叶皮质神经元活动的失活或抑制在很大程度上减少了母鼠对幼崽的搜索和分组。
Brain Res. 2010 Apr 14;1325:77-88. doi: 10.1016/j.brainres.2010.02.027. Epub 2010 Feb 12.
3
Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat.伏隔核多巴胺的变化与大鼠母性行为的个体差异有关。
J Neurosci. 2004 Apr 28;24(17):4113-23. doi: 10.1523/JNEUROSCI.5322-03.2004.
4
Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization.雌性大鼠内侧前额叶皮质损伤会影响性行为和母性行为及其顺序组织。
Behav Neurosci. 2007 Jun;121(3):515-26. doi: 10.1037/0735-7044.121.3.515.
5
Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling.围产期饮食中 ω-3 脂肪酸缺乏会降低大鼠的母性行为：与促炎信号的升高分离。
Nutr Neurosci. 2021 Sep;24(9):735-746. doi: 10.1080/1028415X.2019.1674507. Epub 2019 Oct 10.
6
Postnatal rearing environment alters pup cues for caregiver-offspring interactions.产后养育环境改变了幼仔线索，从而影响了照顾者与幼仔的互动。
Horm Behav. 2024 Sep;165:105630. doi: 10.1016/j.yhbeh.2024.105630. Epub 2024 Aug 25.
7
Serotonin 5-HT and 5-HT receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms.5-羟色胺（Serotonin）5-HT 及其受体通过不同的行为和神经机制调节大鼠的母性行为。
Neuropharmacology. 2020 Jan 1;162:107848. doi: 10.1016/j.neuropharm.2019.107848. Epub 2019 Nov 7.
8
Perioral somatosensory determinants of nursing behavior in Norway rats (Rattus norvegicus).挪威大鼠（褐家鼠）护理行为的口周体感决定因素。
J Comp Psychol. 1989 Sep;103(3):269-80. doi: 10.1037/0735-7036.103.3.269.
9
Comparison of the "nursing" and other parental behaviors of nulliparous and lactating female rats.未生育和哺乳期雌性大鼠“护理”行为及其他母性行为的比较。
Horm Behav. 1999 Dec;36(3):242-51. doi: 10.1006/hbeh.1999.1544.
10
Trigeminal lesions and maternal behavior in Norway rats: III. Experience with pups facilitates recovery.
Dev Psychobiol. 1997 Mar;30(2):115-26. doi: 10.1002/(sici)1098-2302(199703)30:2<115::aid-dev3>3.0.co;2-t.
引用本文的文献
1
PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles.PVN-mPFC OT 投射调节处女期中国田鼠对幼崽的照顾或攻击行为。
Elife. 2024 Oct 16;13:RP96543. doi: 10.7554/eLife.96543.
2
Postpartum State, but Not Maternal Caregiving or Level of Anxiety, Increases Medial Prefrontal Cortex GAD and vGAT in Female Rats.产后状态而非母性行为或焦虑水平会增加雌性大鼠内侧前额叶皮质的谷氨酸脱羧酶（GAD）和囊泡抑制性氨基酸转运体（vGAT）。
Front Glob Womens Health. 2022 Feb 8;2:746518. doi: 10.3389/fgwh.2021.746518. eCollection 2021.
3
Brain Reward Pathway Dysfunction in Maternal Depression and Addiction: A Present and Future Transgenerational Risk.孕期抑郁与成瘾中的脑奖赏通路功能障碍：当前及未来的跨代风险
J Reward Defic Syndr. 2015;1(3):105-116. doi: 10.17756/jrds.2015-017. Epub 2015 Oct 30.
4
Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammals.非人类和人类哺乳动物母性行为背后的共同和不同的心理生物学机制。
Horm Behav. 2015 Jul;73:156-85. doi: 10.1016/j.yhbeh.2015.06.011. Epub 2015 Jun 27.
5
Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period.内侧前额叶皮质中的催产素在产后调节母性关怀、母性攻击和焦虑。
Front Behav Neurosci. 2014 Aug 6;8:258. doi: 10.3389/fnbeh.2014.00258. eCollection 2014.
本文引用的文献
1
A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams.哺乳期大脑的大胆观点：清醒母鼠哺乳时的功能磁共振成像研究。
J Neuroendocrinol. 2011 Nov;23(11):1009-19. doi: 10.1111/j.1365-2826.2011.02184.x.
2
Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats.内侧前额叶皮质神经元活动的失活或抑制在很大程度上减少了母鼠对幼崽的搜索和分组。
Brain Res. 2010 Apr 14;1325:77-88. doi: 10.1016/j.brainres.2010.02.027. Epub 2010 Feb 12.
3
Blood oxygen level-dependent signal responses in corticolimbic 'emotions' circuitry of lactating rats facing intruder threat to pups.面临幼崽受入侵者威胁的哺乳期大鼠皮质边缘“情绪”回路中的血氧水平依赖性信号反应。
Eur J Neurosci. 2009 Sep;30(5):934-45. doi: 10.1111/j.1460-9568.2009.06875.x. Epub 2009 Aug 26.
4
Central vasopressin V1a receptors modulate neural processing in mothers facing intruder threat to pups.中枢血管加压素 V1a 受体调节母亲面对幼崽入侵威胁时的神经处理。
Neuropharmacology. 2010 Jan;58(1):107-16. doi: 10.1016/j.neuropharm.2009.06.023. Epub 2009 Jun 30.
5
What's in a smile? Maternal brain responses to infant facial cues.微笑中蕴含着什么？母亲大脑对婴儿面部线索的反应。
Pediatrics. 2008 Jul;122(1):40-51. doi: 10.1542/peds.2007-1566.
6
Oestrogen receptor alpha localisation in the prefrontal cortex of three mammalian species.雌激素受体α在三种哺乳动物前额叶皮层中的定位
J Neuroendocrinol. 2008 Jul;20(7):893-903. doi: 10.1111/j.1365-2826.2008.01743.x. Epub 2008 Apr 28.
7
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat.大鼠内侧前额叶皮质传入投射的解剖学分析
Brain Struct Funct. 2007 Sep;212(2):149-79. doi: 10.1007/s00429-007-0150-4. Epub 2007 Jul 27.
8
Development of cocaine sensitization before pregnancy affects subsequent maternal retrieval of pups and prefrontal cortical activity during nursing.怀孕前可卡因敏化的发展会影响随后母体对幼崽的找回以及哺乳期间前额叶皮质的活动。
Neuroscience. 2007 Aug 24;148(2):400-12. doi: 10.1016/j.neuroscience.2007.05.026. Epub 2007 Jul 25.
9
Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization.雌性大鼠内侧前额叶皮质损伤会影响性行为和母性行为及其顺序组织。
Behav Neurosci. 2007 Jun;121(3):515-26. doi: 10.1037/0735-7044.121.3.515.
10
Selective delay activity in the medial prefrontal cortex of the rat: contribution of sensorimotor information and contingency.大鼠内侧前额叶皮质中的选择性延迟活动：感觉运动信息和偶然性的作用
J Neurophysiol. 2007 Jul;98(1):303-16. doi: 10.1152/jn.00150.2007. Epub 2007 May 16.
Zotero 插件