Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Curr Allergy Asthma Rep. 2012 Aug;12(4):297-303. doi: 10.1007/s11882-012-0272-5.
Non-IgE-mediated gastrointestinal food allergies, including food-protein-induced enterocolitis, enteropathy, proctocolitis and allergic eosinophilic gastroenteritis, seem to be increasing in several regions in the world. However, unlike the case of IgE-mediated food allergy, development of diagnostic laboratory tests and our understanding of the immunological mechanisms involved in non-IgE-mediated gastrointestinal food allergies lag. Although the clinical entities in Western countries have been well established, the clinical phenotypes might differ somewhat among the human races and geographical regions. In Japan, non-IgE-mediated gastrointestinal food allergies have increased sharply since the late 1990s, and clinicians have sometimes experienced confusion because of differences in the clinical phenotypes from those seen in Western countries. Aiming to solve this problem, we performed clinical research and determined a useful method for dividing patients into four clusters with distinctive clinical symptoms. We are confident this method will help in diagnosing and treating these patients. We also tried to clarify the differences between these patients in Japan and Western countries.
非 IgE 介导的胃肠道食物过敏，包括食物蛋白诱导的结肠炎、肠病、直肠结肠炎和过敏性嗜酸性胃肠炎，在世界上的几个地区似乎正在增加。然而，与 IgE 介导的食物过敏不同，诊断实验室检测的发展和我们对非 IgE 介导的胃肠道食物过敏所涉及的免疫机制的理解落后了。尽管西方国家的临床实体已经得到很好的确立，但在不同种族和地理区域，临床表型可能会有所不同。在日本，自 20 世纪 90 年代末以来，非 IgE 介导的胃肠道食物过敏急剧增加，由于与西方国家所见的临床表型存在差异，临床医生有时会感到困惑。为了解决这个问题，我们进行了临床研究，并确定了一种将患者分为具有独特临床症状的四个聚类的有用方法。我们有信心，这种方法将有助于诊断和治疗这些患者。我们还试图阐明日本和西方国家之间这些患者的差异。
